Detailed information of TA system TA135569

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4654629..4655368
• Replicon: chromosome
• Accession: NZ_CP042355
• Organism: Serratia rubidaea strain H440

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FS595_RS22145
• Protein ID: WP_061321922.1
• Coordinates: 4654889..4655368 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: L0MKT5
• Locus tag: FS595_RS22140
• Protein ID: WP_015962211.1
• Coordinates: 4654629..4654892 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS595_RS22120 (FS595_22165)	4650697..4651377	+	681	WP_015962207.1	GMP/IMP nucleotidase	-
FS595_RS22125 (FS595_22170)	4651374..4651781	+	408	WP_054305077.1	ribosome-associated heat shock protein Hsp15	-
FS595_RS22130 (FS595_22175)	4651807..4652688	+	882	WP_235081975.1	Hsp33 family molecular chaperone HslO	-
FS595_RS22135 (FS595_22180)	4652885..4654504	+	1620	WP_061321923.1	phosphoenolpyruvate carboxykinase (ATP)	-
FS595_RS22140 (FS595_22185)	4654629..4654892	+	264	WP_015962211.1	plasmid stability protein	Antitoxin
FS595_RS22145 (FS595_22190)	4654889..4655368	+	480	WP_061321922.1	type II toxin-antitoxin system VapC family toxin	Toxin
FS595_RS22150 (FS595_22195)	4655402..4656775	-	1374	WP_015962213.1	two-component system sensor histidine kinase EnvZ	-
FS595_RS22155 (FS595_22200)	4656772..4657491	-	720	WP_004709363.1	two-component system response regulator OmpR	-
FS595_RS22160 (FS595_22205)	4657782..4658255	+	474	WP_015962214.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17873.48 Da
• Isoelectric Point: 4.9342

>T135569 WP_061321922.1 NZ_CP042355:4654889-4655368 [Serratia rubidaea]
MIILDTNVISETLRPKPHYNVISWLNEKDNSELYLSAIVVAELFSGVACMPDGKRQQALRLRLAEAIQINFDEQILPFDA
LCAMQYAELMGRNQRQGTPMSAPDAQIAATCLQYGATLATRNTKDFLHCGIELIDPWQVPAGQRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T135569 NZ_CP042355:4654889-4655368 [Serratia rubidaea]
ATGATTATTCTCGATACCAACGTGATCTCAGAAACGCTGCGCCCTAAACCGCATTACAACGTCATCAGTTGGCTGAACGA
AAAAGACAATAGCGAGCTGTACCTCAGCGCCATCGTCGTCGCCGAACTGTTTAGCGGTGTAGCCTGCATGCCGGACGGCA
AACGCCAGCAGGCGCTAAGGCTCAGGCTGGCGGAGGCGATTCAGATTAACTTTGATGAGCAGATTTTGCCGTTTGACGCC
CTGTGTGCGATGCAGTACGCGGAACTGATGGGCAGGAACCAGCGCCAGGGCACGCCGATGAGCGCGCCGGACGCGCAGAT
CGCCGCCACCTGTCTGCAGTACGGCGCCACGCTGGCCACGCGCAATACCAAAGATTTTCTCCATTGCGGCATCGAACTGA
TTGACCCCTGGCAGGTGCCTGCGGGGCAACGCCTGCATGAAGACGCGGCCGAATACTACGTGATGAGCCGCAAATCCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.22 Da
• Isoelectric Point: 5.6211

>AT135569 WP_015962211.1 NZ_CP042355:4654629-4654892 [Serratia rubidaea]
MATITVRNLDDEVKELLRISAAKNGHSMEEEARMILKQALMKKPARYGLGSWMHQHFAEFGGVELAIPPRDAVPPRRVTF
DDDDDQA

Nucleotide

• Length: 264 bp

>AT135569 NZ_CP042355:4654629-4654892 [Serratia rubidaea]
ATGGCTACCATTACCGTCAGAAATCTTGACGACGAGGTCAAAGAGCTGTTGCGTATTTCAGCAGCTAAAAATGGTCATTC
CATGGAAGAGGAGGCGCGCATGATCTTAAAACAGGCGCTGATGAAAAAGCCGGCGCGCTACGGGCTGGGCAGCTGGATGC
ATCAGCACTTCGCCGAATTCGGCGGCGTAGAACTGGCGATCCCGCCGCGCGATGCCGTGCCGCCGCGCCGTGTCACCTTC
GACGATGATGACGACCAGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A126VDX2