Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3918269..3918935 Replicon chromosome
Accession NZ_CP042355
Organism Serratia rubidaea strain H440

Toxin (Protein)


Gene name cptA Uniprot ID A0A4V6JI41
Locus tag FS595_RS18605 Protein ID WP_054306177.1
Coordinates 3918269..3918688 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S4X5M7
Locus tag FS595_RS18610 Protein ID WP_054306178.1
Coordinates 3918669..3918935 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS595_RS18585 (FS595_18635) 3914241..3915971 - 1731 WP_054306184.1 single-stranded-DNA-specific exonuclease RecJ -
FS595_RS18590 (FS595_18640) 3915984..3916700 - 717 WP_054306176.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FS595_RS18595 (FS595_18645) 3916728..3917627 - 900 WP_015673665.1 site-specific tyrosine recombinase XerD -
FS595_RS18600 (FS595_18650) 3917719..3918237 + 519 WP_041411867.1 flavodoxin FldB -
FS595_RS18605 (FS595_18655) 3918269..3918688 - 420 WP_054306177.1 protein YgfX Toxin
FS595_RS18610 (FS595_18660) 3918669..3918935 - 267 WP_054306178.1 FAD assembly factor SdhE Antitoxin
FS595_RS18615 (FS595_18665) 3919275..3920267 + 993 WP_015673669.1 tRNA-modifying protein YgfZ -
FS595_RS18620 (FS595_18670) 3920322..3921002 - 681 WP_015673670.1 hemolysin III family protein -
FS595_RS18625 (FS595_18675) 3921197..3921805 + 609 WP_015673671.1 HD domain-containing protein -
FS595_RS18630 (FS595_18680) 3921837..3923156 - 1320 WP_235081672.1 MFS transporter -
FS595_RS18635 (FS595_18685) 3923153..3923806 - 654 WP_126531529.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16292.19 Da        Isoelectric Point: 11.2220

>T135568 WP_054306177.1 NZ_CP042355:c3918688-3918269 [Serratia rubidaea]
VAQWRCDVRISWRTQLVSLLAHGALILLILISPWPESYDPIWLLLLTLVVFECIRSQTRIASRQGELRLLSAPQRVIWQG
KEWRLARRPWMLRGGMLLTLQASGKRKRRRLWLASDCISSAEWRQLCQRMQLAEDESEG

Download         Length: 420 bp

>T135568 NZ_CP042355:c3918688-3918269 [Serratia rubidaea]
GTGGCCCAGTGGCGATGTGATGTCCGCATCTCCTGGCGTACTCAGCTTGTCTCGCTGTTGGCGCATGGCGCGCTGATACT
GCTGATTCTGATCTCGCCGTGGCCGGAAAGTTACGACCCGATCTGGCTGTTGCTGCTGACGCTGGTGGTTTTCGAATGTA
TTCGCAGTCAGACGCGTATTGCTTCGCGTCAGGGGGAGCTGCGCCTGCTTTCCGCGCCGCAGCGGGTGATTTGGCAGGGC
AAGGAGTGGCGGCTGGCTCGTCGCCCCTGGATGCTGCGCGGCGGCATGCTGCTGACGCTGCAGGCGAGCGGTAAGCGCAA
ACGCCGCCGGCTGTGGCTGGCGTCGGACTGTATCAGCAGCGCCGAGTGGCGGCAGTTGTGCCAGCGGATGCAGCTGGCCG
AGGATGAGTCTGAAGGCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10361.79 Da        Isoelectric Point: 5.0718

>AT135568 WP_054306178.1 NZ_CP042355:c3918935-3918669 [Serratia rubidaea]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDDKALFVRLLQSDDPDLFNWLMNHGAPQDAELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT135568 NZ_CP042355:c3918935-3918669 [Serratia rubidaea]
ATGGATATTAATAACAAAGCGCGTATTCACTGGGCTTGCCGCCGGGGAATGCGTGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGATTCATTGAGCGACGACGACAAGGCGCTGTTCGTGCGTCTGCTGCAGAGCGACGATCCCGATC
TGTTTAACTGGCTGATGAATCATGGCGCCCCGCAGGACGCCGAACTGCAAAGAATGGTGACGCTGATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V6JI41

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4X5M7

References