Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3295193..3295836 Replicon chromosome
Accession NZ_CP042355
Organism Serratia rubidaea strain H440

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FS595_RS15780 Protein ID WP_191977278.1
Coordinates 3295420..3295836 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FS595_RS15775 Protein ID WP_235081521.1
Coordinates 3295193..3295423 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS595_RS15760 (FS595_15815) 3291218..3293281 - 2064 WP_235081520.1 dimethylglycine demethylation protein DgcA -
FS595_RS15765 (FS595_15820) 3293338..3293868 - 531 WP_015673099.1 DUF5943 domain-containing protein -
FS595_RS15770 (FS595_15825) 3293900..3294877 - 978 WP_054307161.1 dipeptidase -
FS595_RS15775 (FS595_15830) 3295193..3295423 + 231 WP_235081521.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FS595_RS15780 (FS595_15835) 3295420..3295836 + 417 WP_191977278.1 type II toxin-antitoxin system VapC family toxin Toxin
FS595_RS15785 (FS595_15840) 3295883..3296968 - 1086 WP_235081522.1 GlxA family transcriptional regulator -
FS595_RS15790 (FS595_15845) 3297318..3298694 - 1377 WP_054307157.1 L-serine ammonia-lyase -
FS595_RS15795 (FS595_15850) 3298982..3300637 + 1656 WP_054307156.1 BCCT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14854.18 Da        Isoelectric Point: 8.2835

>T135567 WP_191977278.1 NZ_CP042355:3295420-3295836 [Serratia rubidaea]
MSHTYMLDTCICSYIMREQPAAAIRRLEQAVMQRHRIVVSAITYAEMRFGAIGKKASPRHAQLVEAFCSRLDAILPWDRA
AVDETTALKAALAAAGTPIGPNDTAIAGHAIATGAILVTNNYKGFARVPGLALEDWSA

Download         Length: 417 bp

>T135567 NZ_CP042355:3295420-3295836 [Serratia rubidaea]
ATGAGCCACACCTACATGCTGGACACCTGTATTTGCTCTTACATTATGCGCGAGCAGCCGGCAGCGGCGATCCGGCGTCT
GGAGCAGGCGGTGATGCAACGCCACCGGATCGTGGTGTCGGCCATTACCTATGCCGAAATGCGCTTTGGTGCGATCGGTA
AAAAGGCCTCACCGCGTCATGCGCAGCTGGTCGAGGCCTTCTGCAGCCGCCTTGACGCCATTTTGCCGTGGGACCGCGCC
GCGGTGGATGAAACCACGGCGCTGAAGGCCGCGTTGGCCGCCGCCGGTACGCCGATCGGGCCCAACGATACCGCAATTGC
CGGCCATGCCATCGCCACTGGCGCCATTCTGGTCACCAATAATTACAAGGGGTTTGCGCGCGTGCCCGGGCTGGCGCTGG
AGGACTGGTCGGCATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8624.78 Da        Isoelectric Point: 4.4563

>AT135567 WP_235081521.1 NZ_CP042355:3295193-3295423 [Serratia rubidaea]
MRTVSVFKNGNNRAIRLPRDMDFAGVNELEIAREGDTIILRPVKPSWGSFLLEDKADADFMTECEDIINDEGRVKP

Download         Length: 231 bp

>AT135567 NZ_CP042355:3295193-3295423 [Serratia rubidaea]
ATGAGAACAGTATCTGTGTTTAAAAACGGCAATAACCGCGCGATCCGCCTGCCCCGCGATATGGATTTTGCAGGCGTCAA
CGAACTGGAGATCGCCCGTGAAGGCGACACCATCATCCTGAGGCCGGTAAAGCCGAGCTGGGGATCGTTTCTGCTGGAAG
ACAAAGCCGATGCGGACTTTATGACGGAATGTGAAGACATCATTAATGACGAGGGACGCGTCAAACCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References