Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3002164..3002804 Replicon chromosome
Accession NZ_CP042355
Organism Serratia rubidaea strain H440

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FS595_RS14370 Protein ID WP_235081423.1
Coordinates 3002164..3002604 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FS595_RS14375 Protein ID WP_235081424.1
Coordinates 3002601..3002804 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS595_RS14350 (FS595_14410) 2997439..2998302 - 864 WP_015672834.1 protein deglycase HchA -
FS595_RS14355 (FS595_14415) 2998441..2998842 - 402 WP_235082821.1 flagellar protein FlhE -
FS595_RS14360 (FS595_14420) 2998845..3000926 - 2082 WP_054307802.1 flagellar biosynthesis protein FlhA -
FS595_RS14365 (FS595_14425) 3000919..3002070 - 1152 WP_054307801.1 flagellar biosynthesis protein FlhB -
FS595_RS14370 (FS595_14430) 3002164..3002604 - 441 WP_235081423.1 type II toxin-antitoxin system VapC family toxin Toxin
FS595_RS14375 (FS595_14435) 3002601..3002804 - 204 WP_235081424.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FS595_RS14380 (FS595_14440) 3002843..3003487 - 645 WP_015672840.1 protein phosphatase CheZ -
FS595_RS14385 (FS595_14445) 3003500..3003889 - 390 WP_054307799.1 chemotaxis response regulator CheY -
FS595_RS14390 (FS595_14450) 3003987..3005036 - 1050 WP_054307798.1 chemotaxis response regulator protein-glutamate methylesterase -
FS595_RS14395 (FS595_14455) 3005036..3005896 - 861 WP_054307797.1 protein-glutamate O-methyltransferase CheR -
FS595_RS14400 (FS595_14460) 3005925..3007529 - 1605 WP_235081425.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16223.66 Da        Isoelectric Point: 8.9245

>T135566 WP_235081423.1 NZ_CP042355:c3002604-3002164 [Serratia rubidaea]
MITHMLDTNIVIYVIKRRPREVLAVFNQHAGKMAISAVTYGELVHGVEKSARQVENLRVVEDFVSRLDVLPYTDKAAAHY
GNIRADLERKGTPIGVNDLHIAGHARSEGLVLVSNNLREFACIDGLRLENWLSSPIIPPSRPSSSK

Download         Length: 441 bp

>T135566 NZ_CP042355:c3002604-3002164 [Serratia rubidaea]
ATGATCACGCATATGCTGGATACCAATATTGTCATCTATGTGATCAAGCGTCGACCGCGTGAAGTGCTGGCGGTATTTAA
TCAGCACGCGGGAAAAATGGCGATATCTGCCGTGACCTATGGTGAGCTTGTGCACGGCGTGGAAAAGAGCGCCAGGCAGG
TTGAGAATCTGCGCGTCGTCGAGGATTTTGTTTCCCGGCTGGACGTTTTGCCCTACACCGACAAGGCGGCTGCACACTAC
GGCAATATTCGCGCCGATCTTGAACGTAAAGGCACGCCGATTGGGGTTAACGACCTGCATATCGCCGGCCATGCCCGCAG
TGAAGGCTTGGTATTGGTCAGCAATAATTTGCGCGAGTTTGCCTGCATCGACGGTCTGAGGCTGGAAAACTGGTTGTCAT
CACCAATCATTCCGCCATCTCGTCCCTCATCCTCGAAATAA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7738.60 Da        Isoelectric Point: 5.0644

>AT135566 WP_235081424.1 NZ_CP042355:c3002804-3002601 [Serratia rubidaea]
MRNVAHPAKARFPDSVSKVTVRVVGKERVLAPVENTWDSFFDQERLPGDDFLNERAAQYQAERESFE

Download         Length: 204 bp

>AT135566 NZ_CP042355:c3002804-3002601 [Serratia rubidaea]
TTGCGAAACGTTGCGCATCCTGCAAAGGCGCGTTTTCCTGATTCGGTGTCGAAGGTGACGGTGCGCGTGGTGGGTAAAGA
GCGCGTTCTGGCCCCGGTGGAAAATACCTGGGACAGCTTTTTTGACCAGGAGCGTCTGCCCGGTGATGATTTTCTGAATG
AAAGAGCCGCGCAGTATCAGGCAGAGCGGGAAAGTTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References