Detailed information of TA system TA135555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4654847..4655586
• Replicon: chromosome
• Accession: NZ_CP042353
• Organism: Serratia rubidaea strain H469

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FS596_RS22155
• Protein ID: WP_061321922.1
• Coordinates: 4655107..4655586 (+)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: L0MKT5
• Locus tag: FS596_RS22150
• Protein ID: WP_015962211.1
• Coordinates: 4654847..4655110 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS596_RS22130 (FS596_22170)	4650915..4651595	+	681	WP_015962207.1	GMP/IMP nucleotidase	-
FS596_RS22135 (FS596_22175)	4651592..4651999	+	408	WP_054305077.1	ribosome-associated heat shock protein Hsp15	-
FS596_RS22140 (FS596_22180)	4652025..4652906	+	882	WP_235081975.1	Hsp33 family molecular chaperone HslO	-
FS596_RS22145 (FS596_22185)	4653103..4654722	+	1620	WP_061321923.1	phosphoenolpyruvate carboxykinase (ATP)	-
FS596_RS22150 (FS596_22190)	4654847..4655110	+	264	WP_015962211.1	plasmid stability protein	Antitoxin
FS596_RS22155 (FS596_22195)	4655107..4655586	+	480	WP_061321922.1	type II toxin-antitoxin system VapC family toxin	Toxin
FS596_RS22160 (FS596_22200)	4655620..4656993	-	1374	WP_015962213.1	two-component system sensor histidine kinase EnvZ	-
FS596_RS22165 (FS596_22205)	4656990..4657709	-	720	WP_004709363.1	two-component system response regulator OmpR	-
FS596_RS22170 (FS596_22210)	4658000..4658473	+	474	WP_015962214.1	transcription elongation factor GreB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17873.48 Da
• Isoelectric Point: 4.9342

>T135555 WP_061321922.1 NZ_CP042353:4655107-4655586 [Serratia rubidaea]
MIILDTNVISETLRPKPHYNVISWLNEKDNSELYLSAIVVAELFSGVACMPDGKRQQALRLRLAEAIQINFDEQILPFDA
LCAMQYAELMGRNQRQGTPMSAPDAQIAATCLQYGATLATRNTKDFLHCGIELIDPWQVPAGQRLHEDAAEYYVMSRKS

Nucleotide

• Length: 480 bp

>T135555 NZ_CP042353:4655107-4655586 [Serratia rubidaea]
ATGATTATTCTCGATACCAACGTGATCTCAGAAACGCTGCGCCCTAAACCGCATTACAACGTCATCAGTTGGCTGAACGA
AAAAGACAATAGCGAGCTGTACCTCAGCGCCATCGTCGTCGCCGAACTGTTTAGCGGTGTAGCCTGCATGCCGGACGGCA
AACGCCAGCAGGCGCTAAGGCTCAGGCTGGCGGAGGCGATTCAGATTAACTTTGATGAGCAGATTTTGCCGTTTGACGCC
CTGTGTGCGATGCAGTACGCGGAACTGATGGGCAGGAACCAGCGCCAGGGCACGCCGATGAGCGCGCCGGACGCGCAGAT
CGCCGCCACCTGTCTGCAGTACGGCGCCACGCTGGCCACGCGCAATACCAAAGATTTTCTCCATTGCGGCATCGAACTGA
TTGACCCCTGGCAGGTGCCTGCGGGGCAACGCCTGCATGAAGACGCGGCCGAATACTACGTGATGAGCCGCAAATCCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9834.22 Da
• Isoelectric Point: 5.6211

>AT135555 WP_015962211.1 NZ_CP042353:4654847-4655110 [Serratia rubidaea]
MATITVRNLDDEVKELLRISAAKNGHSMEEEARMILKQALMKKPARYGLGSWMHQHFAEFGGVELAIPPRDAVPPRRVTF
DDDDDQA

Nucleotide

• Length: 264 bp

>AT135555 NZ_CP042353:4654847-4655110 [Serratia rubidaea]
ATGGCTACCATTACCGTCAGAAATCTTGACGACGAGGTCAAAGAGCTGTTGCGTATTTCAGCAGCTAAAAATGGTCATTC
CATGGAAGAGGAGGCGCGCATGATCTTAAAACAGGCGCTGATGAAAAAGCCGGCGCGCTACGGGCTGGGCAGCTGGATGC
ATCAGCACTTCGCCGAATTCGGCGGCGTAGAACTGGCGATCCCGCCGCGCGATGCCGTGCCGCCGCGCCGTGTCACCTTC
GACGATGATGACGACCAGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A126VDX2