Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3295199..3295842 Replicon chromosome
Accession NZ_CP042353
Organism Serratia rubidaea strain H469

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FS596_RS15780 Protein ID WP_191977278.1
Coordinates 3295426..3295842 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FS596_RS15775 Protein ID WP_235081521.1
Coordinates 3295199..3295429 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS596_RS15760 (FS596_15815) 3291224..3293287 - 2064 WP_235081520.1 dimethylglycine demethylation protein DgcA -
FS596_RS15765 (FS596_15820) 3293344..3293874 - 531 WP_015673099.1 DUF5943 domain-containing protein -
FS596_RS15770 (FS596_15825) 3293906..3294883 - 978 WP_054307161.1 dipeptidase -
FS596_RS15775 (FS596_15830) 3295199..3295429 + 231 WP_235081521.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FS596_RS15780 (FS596_15835) 3295426..3295842 + 417 WP_191977278.1 type II toxin-antitoxin system VapC family toxin Toxin
FS596_RS15785 (FS596_15840) 3295889..3296974 - 1086 WP_235081522.1 GlxA family transcriptional regulator -
FS596_RS15790 (FS596_15845) 3297324..3298700 - 1377 WP_054307157.1 L-serine ammonia-lyase -
FS596_RS15795 (FS596_15850) 3298988..3300643 + 1656 WP_054307156.1 BCCT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14854.18 Da        Isoelectric Point: 8.2835

>T135553 WP_191977278.1 NZ_CP042353:3295426-3295842 [Serratia rubidaea]
MSHTYMLDTCICSYIMREQPAAAIRRLEQAVMQRHRIVVSAITYAEMRFGAIGKKASPRHAQLVEAFCSRLDAILPWDRA
AVDETTALKAALAAAGTPIGPNDTAIAGHAIATGAILVTNNYKGFARVPGLALEDWSA

Download         Length: 417 bp

>T135553 NZ_CP042353:3295426-3295842 [Serratia rubidaea]
ATGAGCCACACCTACATGCTGGACACCTGTATTTGCTCTTACATTATGCGCGAGCAGCCGGCAGCGGCGATCCGGCGTCT
GGAGCAGGCGGTGATGCAACGCCACCGGATCGTGGTGTCGGCCATTACCTATGCCGAAATGCGCTTTGGTGCGATCGGTA
AAAAGGCCTCACCGCGTCATGCGCAGCTGGTCGAGGCCTTCTGCAGCCGCCTTGACGCCATTTTGCCGTGGGACCGCGCC
GCGGTGGATGAAACCACGGCGCTGAAGGCCGCGTTGGCCGCCGCCGGTACGCCGATCGGGCCCAACGATACCGCAATTGC
CGGCCATGCCATCGCCACTGGCGCCATTCTGGTCACCAATAATTACAAGGGGTTTGCGCGCGTGCCCGGGCTGGCGCTGG
AGGACTGGTCGGCATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8624.78 Da        Isoelectric Point: 4.4563

>AT135553 WP_235081521.1 NZ_CP042353:3295199-3295429 [Serratia rubidaea]
MRTVSVFKNGNNRAIRLPRDMDFAGVNELEIAREGDTIILRPVKPSWGSFLLEDKADADFMTECEDIINDEGRVKP

Download         Length: 231 bp

>AT135553 NZ_CP042353:3295199-3295429 [Serratia rubidaea]
ATGAGAACAGTATCTGTGTTTAAAAACGGCAATAACCGCGCGATCCGCCTGCCCCGCGATATGGATTTTGCAGGCGTCAA
CGAACTGGAGATCGCCCGTGAAGGCGACACCATCATCCTGAGGCCGGTAAAGCCGAGCTGGGGATCGTTTCTGCTGGAAG
ACAAAGCCGATGCGGACTTTATGACGGAATGTGAAGACATCATTAATGACGAGGGACGCGTCAAACCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References