Detailed information of TA system TA135542

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 916308..916843
• Replicon: chromosome
• Accession: NZ_CP042353
• Organism: Serratia rubidaea strain H469

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FS596_RS04285
• Protein ID: WP_191976702.1
• Coordinates: 916308..916595 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3S4H852
• Locus tag: FS596_RS04290
• Protein ID: WP_054305340.1
• Coordinates: 916592..916843 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS596_RS04270 (FS596_04325)	911902..913647	-	1746	WP_054307426.1	IucA/IucC family protein	-
FS596_RS04275 (FS596_04330)	913786..914988	+	1203	WP_235082328.1	MFS transporter	-
FS596_RS04280 (FS596_04335)	915010..915888	+	879	WP_235082329.1	siderophore-interacting protein	-
FS596_RS04285 (FS596_04340)	916308..916595	-	288	WP_191976702.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FS596_RS04290 (FS596_04345)	916592..916843	-	252	WP_054305340.1	antitoxin	Antitoxin
FS596_RS04295 (FS596_04350)	916927..917700	-	774	WP_235082330.1	amidohydrolase	-
FS596_RS04300 (FS596_04355)	917688..918848	-	1161	WP_015671076.1	pyridoxal phosphate-dependent aminotransferase	-
FS596_RS04305 (FS596_04360)	918983..919597	+	615	WP_212603212.1	methylthioribulose 1-phosphate dehydratase	-
FS596_RS04310 (FS596_04365)	919594..920280	+	687	WP_235082331.1	acireductone synthase	-
FS596_RS04315 (FS596_04370)	920280..920822	+	543	WP_235082332.1	acireductone dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10919.99 Da
• Isoelectric Point: 10.5563

>T135542 WP_191976702.1 NZ_CP042353:c916595-916308 [Serratia rubidaea]
MTHKVKFRESALKEWNRLDKALQQQFAKKLKKCCENPHIPAAKLRGMPGCYKIKLRASGFRLVYEVIDDCLVIAVVAVGK
RERGSVYQLSSERLK

Nucleotide

• Length: 288 bp

>T135542 NZ_CP042353:c916595-916308 [Serratia rubidaea]
ATGACCCACAAGGTCAAATTCCGCGAGTCTGCGCTGAAAGAGTGGAACAGGCTGGATAAAGCGCTACAGCAACAGTTTGC
CAAGAAGCTGAAGAAATGCTGTGAAAATCCCCATATCCCCGCGGCGAAACTACGTGGCATGCCGGGGTGTTACAAAATCA
AGCTGCGGGCCTCTGGATTTCGGTTGGTCTATGAAGTGATCGACGATTGTTTGGTGATCGCCGTCGTTGCCGTCGGTAAG
CGGGAGCGAGGCAGCGTTTACCAATTAAGCAGCGAACGTCTGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9250.48 Da
• Isoelectric Point: 3.9798

>AT135542 WP_054305340.1 NZ_CP042353:c916843-916592 [Serratia rubidaea]
VPNIILSDTSASISELKKNPMGTVNAGEGYPVAILNRNQPAFYCVPAALYEQMLDVLDEQELVRLVNERRNEALIDVDLD
QFT

Nucleotide

• Length: 252 bp

>AT135542 NZ_CP042353:c916843-916592 [Serratia rubidaea]
GTGCCAAATATCATTCTGAGCGATACCAGCGCCAGCATCAGCGAACTGAAGAAAAACCCCATGGGGACGGTCAACGCCGG
CGAAGGGTATCCGGTCGCCATCCTCAACCGTAATCAGCCCGCATTCTATTGCGTACCGGCAGCCCTGTACGAGCAAATGC
TTGACGTGCTGGATGAGCAGGAACTGGTCAGGCTGGTCAATGAGCGTCGCAACGAAGCACTGATTGACGTCGATCTGGAC
CAGTTTACATGA

Structures

Antitoxin

• AlphaFold DB: A0A3S4H852