Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4310040..4310838 Replicon chromosome
Accession NZ_CP042350
Organism Escherichia coli strain RM10410

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8S7MZH4
Locus tag FS611_RS21705 Protein ID WP_001094453.1
Coordinates 4310461..4310838 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8S7WAC0
Locus tag FS611_RS21700 Protein ID WP_001285601.1
Coordinates 4310040..4310414 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS611_RS21675 4307415..4307648 + 234 WP_001117559.1 DUF905 family protein -
FS611_RS21680 4307738..4308556 + 819 WP_032280902.1 DUF945 domain-containing protein -
FS611_RS21685 4308611..4309144 + 534 WP_000849595.1 antirestriction protein -
FS611_RS21690 4309111..4309587 + 477 WP_001186727.1 RadC family protein -
FS611_RS21695 4309656..4309877 + 222 WP_000692296.1 DUF987 domain-containing protein -
FS611_RS21700 4310040..4310414 + 375 WP_001285601.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FS611_RS21705 4310461..4310838 + 378 WP_001094453.1 TA system toxin CbtA family protein Toxin
FS611_RS21710 4310835..4311323 + 489 WP_000761711.1 hypothetical protein -
FS611_RS21715 4311335..4311532 + 198 WP_000839249.1 DUF957 domain-containing protein -
FS611_RS21720 4311617..4312462 + 846 WP_001280520.1 DUF4942 domain-containing protein -
FS611_RS21730 4313255..4314439 + 1185 WP_001172876.1 sugar efflux transporter -
FS611_RS21735 4314550..4315473 + 924 WP_000535961.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14181.04 Da        Isoelectric Point: 5.5831

>T135509 WP_001094453.1 NZ_CP042350:4310461-4310838 [Escherichia coli]
MNTLPDTHVRETSGCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T135509 NZ_CP042350:4310461-4310838 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13653.47 Da        Isoelectric Point: 5.5769

>AT135509 WP_001285601.1 NZ_CP042350:4310040-4310414 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLEQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT135509 NZ_CP042350:4310040-4310414 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCGGATTCGTACCACCTGGAGCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTCAGCCCCCGCTATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References