Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 888873..889350 Replicon chromosome
Accession NZ_CP042348
Organism Staphylococcus aureus strain BSN9R

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag FSN22_RS04385 Protein ID WP_000052078.1
Coordinates 888873..889061 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FSN22_RS04390 Protein ID WP_001059690.1
Coordinates 889090..889350 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSN22_RS04355 884914..885384 + 471 WP_000824472.1 hypothetical protein -
FSN22_RS04360 885725..886411 + 687 WP_001548082.1 thermonuclease family protein -
FSN22_RS04365 886768..886968 + 201 WP_001059082.1 cold-shock protein -
FSN22_RS04370 887464..887682 - 219 WP_000005886.1 hypothetical protein -
FSN22_RS04375 887744..888028 - 285 WP_001004395.1 hypothetical protein -
FSN22_RS04380 888116..888685 - 570 WP_001106654.1 hypothetical protein -
FSN22_RS04385 888873..889061 - 189 WP_000052078.1 hypothetical protein Toxin
FSN22_RS04390 889090..889350 - 261 WP_001059690.1 hypothetical protein Antitoxin
FSN22_RS04395 889691..889894 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FSN22_RS04400 889891..890127 - 237 WP_000368687.1 hypothetical protein -
FSN22_RS04405 890352..890933 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
FSN22_RS04410 891006..891623 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
FSN22_RS04415 891778..892272 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
FSN22_RS04420 892671..893093 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
FSN22_RS04425 893241..893957 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 883557..914639 31082


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-261)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(96-247)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T135471 WP_000052078.1 NZ_CP042348:c889061-888873 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T135471 NZ_CP042348:c889061-888873 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT135471 WP_001059690.1 NZ_CP042348:c889350-889090 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT135471 NZ_CP042348:c889350-889090 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References