Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2144203..2144732 Replicon chromosome
Accession NZ_CP042345
Organism Novosphingobium ginsenosidimutans strain FW-6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FRF71_RS10645 Protein ID WP_161597948.1
Coordinates 2144203..2144493 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag FRF71_RS10650 Protein ID WP_147090632.1
Coordinates 2144490..2144732 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRF71_RS10620 2139544..2140449 - 906 WP_161597947.1 subclass B3 metallo-beta-lactamase -
FRF71_RS10625 2140439..2141158 - 720 WP_147090627.1 SDR family oxidoreductase -
FRF71_RS10630 2141281..2141670 + 390 WP_147090628.1 succinate dehydrogenase, cytochrome b556 subunit -
FRF71_RS10635 2141682..2142068 + 387 WP_147090629.1 succinate dehydrogenase, hydrophobic membrane anchor protein -
FRF71_RS10640 2142065..2143870 + 1806 WP_147090630.1 succinate dehydrogenase flavoprotein subunit -
FRF71_RS10645 2144203..2144493 - 291 WP_161597948.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FRF71_RS10650 2144490..2144732 - 243 WP_147090632.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FRF71_RS10655 2145149..2145535 + 387 WP_147090633.1 BlaI/MecI/CopY family transcriptional regulator -
FRF71_RS10660 2145532..2147067 + 1536 WP_147090634.1 hypothetical protein -
FRF71_RS10665 2147133..2148281 - 1149 WP_147090635.1 alpha-hydroxy-acid oxidizing protein -
FRF71_RS10670 2148318..2148956 - 639 WP_147090636.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin

Antitoxin ParD

(2-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11196.82 Da        Isoelectric Point: 11.0976

>T135454 WP_161597948.1 NZ_CP042345:c2144493-2144203 [Novosphingobium ginsenosidimutans]
VRTLEFRAAAVADLRRTARETRARWGQAQAAHYVATLRDDIKSRLEFPLRFPEYEPRPGLRRMNSGRHAVFYLVFEDRIE
IVRVLHAAAGFETWLG

Download         Length: 291 bp

>T135454 NZ_CP042345:c2144493-2144203 [Novosphingobium ginsenosidimutans]
GTGAGAACGCTGGAATTCCGCGCCGCCGCCGTGGCCGATCTGCGGCGCACGGCGCGGGAAACACGCGCGCGCTGGGGGCA
AGCACAGGCGGCGCATTATGTCGCCACGCTCCGGGATGACATCAAATCGCGGCTGGAGTTCCCACTGCGCTTCCCCGAAT
ACGAACCTCGCCCCGGCTTGCGCCGGATGAACAGTGGCCGCCATGCAGTGTTCTATCTGGTGTTCGAGGACCGGATCGAG
ATCGTCCGAGTGCTGCACGCAGCGGCAGGCTTCGAGACCTGGTTGGGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9043.05 Da        Isoelectric Point: 4.8605

>AT135454 WP_147090632.1 NZ_CP042345:c2144732-2144490 [Novosphingobium ginsenosidimutans]
MASKNTSIALGERYVAYTRSKVESGEYGSASEVIRDALRLHEERAAFRAKLLEAIDQGLTSPVDAEFDLDRWYGEEFRAK

Download         Length: 243 bp

>AT135454 NZ_CP042345:c2144732-2144490 [Novosphingobium ginsenosidimutans]
ATGGCCAGCAAGAACACCTCGATCGCCCTTGGTGAGCGCTATGTTGCTTACACCCGCAGCAAAGTGGAATCAGGCGAATA
CGGATCAGCCAGCGAAGTCATCCGCGATGCACTGCGCCTGCATGAAGAGCGGGCAGCGTTCCGCGCCAAGCTGCTTGAGG
CGATCGATCAGGGGCTGACCAGCCCGGTCGATGCCGAATTTGATCTCGACCGCTGGTACGGCGAGGAATTCAGAGCGAAG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References