Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1328555..1329257 Replicon chromosome
Accession NZ_CP042344
Organism Comamonas sp. NLF-7-7 strain NLF 7-7

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag FOZ74_RS06460 Protein ID WP_146914107.1
Coordinates 1328555..1328935 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag FOZ74_RS06465 Protein ID WP_146912286.1
Coordinates 1328916..1329257 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOZ74_RS06440 1324861..1326225 - 1365 WP_146912282.1 MBL fold metallo-hydrolase -
FOZ74_RS06445 1326243..1326608 - 366 WP_146912283.1 ribbon-helix-helix domain-containing protein -
FOZ74_RS06450 1326808..1327389 - 582 WP_146912284.1 DJ-1/PfpI family protein -
FOZ74_RS06455 1327480..1328310 - 831 WP_146912285.1 SDR family oxidoreductase -
FOZ74_RS06460 1328555..1328935 + 381 WP_146914107.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOZ74_RS06465 1328916..1329257 + 342 WP_146912286.1 helix-turn-helix domain-containing protein Antitoxin
FOZ74_RS06470 1329306..1332377 + 3072 WP_146912287.1 class I SAM-dependent DNA methyltransferase -
FOZ74_RS06475 1332374..1332643 + 270 WP_146912288.1 hypothetical protein -
FOZ74_RS06480 1332677..1333324 - 648 WP_146912289.1 thiamine phosphate synthase -
FOZ74_RS06485 1333321..1334139 - 819 WP_146912290.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-96)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13929.99 Da        Isoelectric Point: 7.4212

>T135450 WP_146914107.1 NZ_CP042344:1328555-1328935 [Comamonas sp. NLF-7-7]
MHEPGIKPLEWIASSKKDLMAMPREVQDTFGYALHLAQTGDKADAAKVLKGFGGAGVLEVVESDEGGTYRAVYTVKFAEA
VFVLHCFQKKSRRGTATPKEDMDMVHARLKVAEAIARELEHEKANR

Download         Length: 381 bp

>T135450 NZ_CP042344:1328555-1328935 [Comamonas sp. NLF-7-7]
ATGCACGAACCAGGCATCAAACCACTGGAATGGATCGCTTCAAGCAAGAAAGACCTGATGGCGATGCCCCGCGAGGTGCA
AGACACTTTCGGATATGCCTTGCATCTGGCCCAGACGGGTGACAAGGCTGATGCCGCCAAGGTGCTCAAGGGCTTTGGCG
GGGCGGGCGTGCTGGAGGTGGTGGAAAGCGATGAAGGCGGCACGTACCGCGCCGTGTACACGGTCAAGTTCGCCGAGGCG
GTCTTTGTGCTGCACTGCTTTCAGAAAAAGTCCAGGCGCGGCACGGCTACGCCCAAGGAAGACATGGACATGGTTCATGC
CCGGTTGAAGGTGGCCGAGGCGATAGCACGGGAGTTGGAACATGAAAAAGCGAATCGTTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12379.60 Da        Isoelectric Point: 10.2042

>AT135450 WP_146912286.1 NZ_CP042344:1328916-1329257 [Comamonas sp. NLF-7-7]
MKKRIVEGIEVERGSGNVYADLGLPGADEMLVKARLVTKIREIIKAHGWTQQEAAQVLGMPQPKLSNMLRGQFRGISEAK
LMACLARLGRRVQIVIGPDPQVETTGVVEVIFA

Download         Length: 342 bp

>AT135450 NZ_CP042344:1328916-1329257 [Comamonas sp. NLF-7-7]
ATGAAAAAGCGAATCGTTGAAGGTATCGAGGTAGAGCGCGGCTCGGGCAATGTCTATGCCGACCTGGGCTTGCCGGGGGC
CGATGAGATGCTGGTGAAGGCCAGGCTGGTAACGAAGATCCGGGAGATCATCAAGGCGCACGGCTGGACTCAGCAAGAGG
CCGCGCAGGTGCTGGGCATGCCGCAGCCCAAGTTGTCGAACATGCTGCGCGGGCAGTTCCGGGGCATCAGCGAGGCCAAG
CTGATGGCGTGCCTGGCCCGTTTGGGGCGCAGAGTCCAGATCGTGATCGGCCCTGATCCGCAAGTAGAGACGACGGGGGT
TGTTGAAGTGATATTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References