Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 574014..574621 Replicon chromosome
Accession NZ_CP042344
Organism Comamonas sp. NLF-7-7 strain NLF 7-7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FOZ74_RS02925 Protein ID WP_146911669.1
Coordinates 574331..574621 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag FOZ74_RS02920 Protein ID WP_146911668.1
Coordinates 574014..574316 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOZ74_RS02895 569096..570577 - 1482 WP_146911663.1 ribonuclease G -
FOZ74_RS02900 570607..571227 - 621 WP_146911664.1 septum formation inhibitor Maf -
FOZ74_RS02905 571327..572349 + 1023 WP_146911665.1 ABC transporter substrate-binding protein -
FOZ74_RS02910 572356..573168 + 813 WP_146911666.1 ABC transporter ATP-binding protein -
FOZ74_RS02915 573179..574006 + 828 WP_146911667.1 ABC transporter permease -
FOZ74_RS02920 574014..574316 - 303 WP_146911668.1 putative addiction module antidote protein Antitoxin
FOZ74_RS02925 574331..574621 - 291 WP_146911669.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOZ74_RS02930 574685..575152 - 468 WP_146911670.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
FOZ74_RS02935 575165..575842 - 678 WP_146911671.1 ribosome silencing factor -
FOZ74_RS02940 575943..576881 - 939 WP_146911672.1 oxygen-dependent coproporphyrinogen oxidase -
FOZ74_RS02945 576878..578152 - 1275 WP_146911673.1 phosphoribosylamine--glycine ligase -
FOZ74_RS02950 578180..578899 - 720 WP_146911674.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-95)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10917.54 Da        Isoelectric Point: 8.0883

>T135449 WP_146911669.1 NZ_CP042344:c574621-574331 [Comamonas sp. NLF-7-7]
MTVIHTTETFDDWFDALRDKHAQKRIQARIRRAELGNFGDCAPVGEGVSEMRIHHGPGYRVYFVQRGLEIVILLAGGDKS
TQRLDIKLALELARQL

Download         Length: 291 bp

>T135449 NZ_CP042344:c574621-574331 [Comamonas sp. NLF-7-7]
ATGACGGTCATTCATACCACCGAAACGTTTGATGACTGGTTTGACGCATTGCGCGACAAGCACGCACAAAAGCGTATTCA
GGCGCGCATCAGGCGTGCTGAACTTGGAAATTTTGGGGATTGCGCGCCTGTGGGTGAGGGTGTATCGGAGATGCGCATTC
ACCATGGGCCGGGGTATCGCGTGTATTTCGTGCAGCGAGGTCTGGAAATTGTCATCCTGCTCGCCGGTGGCGACAAGTCA
ACCCAGCGTTTGGATATCAAGCTGGCACTCGAACTGGCGCGGCAGTTGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10713.36 Da        Isoelectric Point: 5.6926

>AT135449 WP_146911668.1 NZ_CP042344:c574316-574014 [Comamonas sp. NLF-7-7]
MGTIKLRRWDSAEHLKTEEDIVLYLQACMEEAGDDAAFIAAALGDIARARGMTQLAKETGLGRESLYKALSGEGNPSFGT
VLKVMHALGIKLQALPVNPA

Download         Length: 303 bp

>AT135449 NZ_CP042344:c574316-574014 [Comamonas sp. NLF-7-7]
ATGGGAACGATCAAACTACGCCGATGGGACAGCGCAGAGCACCTCAAGACCGAAGAGGACATCGTGCTGTATTTGCAAGC
CTGCATGGAAGAGGCGGGTGATGATGCGGCTTTCATCGCGGCAGCGCTGGGCGATATTGCCCGCGCCCGTGGCATGACCC
AGCTCGCCAAGGAAACCGGTCTGGGCCGCGAAAGCCTCTACAAGGCGCTGTCGGGAGAAGGCAACCCGAGCTTTGGCACT
GTCCTGAAGGTCATGCACGCCCTGGGAATCAAGCTGCAGGCCCTGCCGGTGAACCCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References