Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1030868..1031674 Replicon chromosome
Accession NZ_CP042341
Organism Staphylococcus capitis strain BN2

Toxin (Protein)


Gene name tsbT Uniprot ID A0A1J4EAU5
Locus tag FRG19_RS04965 Protein ID WP_002434789.1
Coordinates 1031495..1031674 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A1J4ECT8
Locus tag FRG19_RS04960 Protein ID WP_002453580.1
Coordinates 1030868..1031467 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRG19_RS04940 1026757..1028214 + 1458 Protein_936 ABC transporter substrate-binding protein/permease -
FRG19_RS04945 1028207..1028929 + 723 WP_064212285.1 amino acid ABC transporter ATP-binding protein -
FRG19_RS04950 1029052..1030215 + 1164 WP_087671673.1 tRNA epoxyqueuosine(34) reductase QueG -
FRG19_RS04955 1030218..1030688 + 471 WP_023350044.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
FRG19_RS04960 1030868..1031467 + 600 WP_002453580.1 glucosamine-6-phosphate isomerase Antitoxin
FRG19_RS04965 1031495..1031674 + 180 WP_002434789.1 hypothetical protein Toxin
FRG19_RS04970 1031839..1032237 + 399 WP_049428016.1 hypothetical protein -
FRG19_RS04975 1032391..1033776 + 1386 WP_002434798.1 class II fumarate hydratase -
FRG19_RS04980 1033874..1034704 - 831 WP_002434696.1 RluA family pseudouridine synthase -
FRG19_RS04985 1034880..1035992 + 1113 WP_037549760.1 GAF domain-containing sensor histidine kinase -
FRG19_RS04990 1036012..1036635 + 624 WP_002434769.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7005.38 Da        Isoelectric Point: 3.9242

>T135442 WP_002434789.1 NZ_CP042341:1031495-1031674 [Staphylococcus capitis]
MNKEHESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLNNE

Download         Length: 180 bp

>T135442 NZ_CP042341:1031495-1031674 [Staphylococcus capitis]
ATGAATAAAGAACATGAATCTAAATTGAATTATCATGAAGAAGAAAATGCTATGGTTACAGATTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAAATTTCAGAAGAAAATGATGAAGATAAATTAAACCAATCTCATGATGAAGATGTTCGTT
CTGACCTTAATAATGAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22720.63 Da        Isoelectric Point: 4.7928

>AT135442 WP_002453580.1 NZ_CP042341:1030868-1031467 [Staphylococcus capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp

>AT135442 NZ_CP042341:1030868-1031467 [Staphylococcus capitis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAGTGAAAGAGTAGCAGAATATGCTGCAGATATTATTCGTAAACAATTTAA
TAATAATCCAACTACAATTGCAGGTTTTCACTTAGAAAAAGATCACGCACCTGTATTAGATGAACTTAAGAAAAATGTAG
ATACGCATGCTGTAGATTTCAGCCAAATCAATATTTTAGATTATGATGATAATAGATCTTATTATGAAGCATTAGGTGTA
CCTGAAAGCCAAGTGTATTCAATTTCTTACGAACAAGATGCAATTGATTTTATTTCAGATAAAATGAAAACTAAAGAAAA
TAAAGGTAAATTAATCCTTCAAGTTCTTTCAATTGATGAAAGTGGCAAGTTAGATGTAAGTGTACGTCAAGGTCTTATGG
AAGCTAGAGAAATTTTCTTAGTTGTTACAGGTAGTAATAAACGTGAAGTTATTGAAAAACTTTATCGTGAAAACGGTAAA
TCTAGTTATGAGCCAGCAGATCTTAAAGCACACCGCATGGTAAATGTTATTTTAGATAAAGAAGCGGCTGCAGGATTACC
TGAGGATGTTAAAGAATACTTCACAGCACGTTATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4EAU5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4ECT8

References