Detailed information of TA system TA135440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 856549..857063
• Replicon: chromosome
• Accession: NZ_CP042341
• Organism: Staphylococcus capitis strain BN2

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: FRG19_RS03980
• Protein ID: WP_194251429.1
• Coordinates: 856857..857063 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A1J4E888
• Locus tag: FRG19_RS03975
• Protein ID: WP_002435858.1
• Coordinates: 856549..856842 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FRG19_RS03950	851707..852495	+	789	WP_002435520.1	hydroxyethylthiazole kinase	-
FRG19_RS03955	852502..853140	+	639	WP_037551262.1	thiamine phosphate synthase	-
FRG19_RS03960	853229..854101	+	873	WP_002435877.1	membrane protein insertase YidC	-
FRG19_RS03965	854160..854822	-	663	WP_002453696.1	HD domain-containing protein	-
FRG19_RS03970	854879..856363	-	1485	WP_002435854.1	cardiolipin synthase	-
FRG19_RS03975	856549..856842	+	294	WP_002435858.1	copper-sensing transcriptional repressor CsoR	Antitoxin
FRG19_RS03980	856857..857063	+	207	WP_194251429.1	heavy-metal-associated domain-containing protein	Toxin
FRG19_RS03985	857200..857337	+	138	WP_002435861.1	hypothetical protein	-
FRG19_RS03990	857393..858604	-	1212	WP_064212371.1	rod shape-determining protein RodA	-
FRG19_RS03995	859009..860079	+	1071	WP_194251430.1	D-alanine--D-alanine ligase	-
FRG19_RS04000	860095..861450	+	1356	WP_049427292.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7820.87 Da
• Isoelectric Point: 4.2987

>T135440 WP_194251429.1 NZ_CP042341:856857-857063 [Staphylococcus capitis]
MENGIVYVANIETIEEENQLKTRLENMIGVEKVDIDSKVGEIKVLFETPANLNSIEKEVYNSGFRVRY

Nucleotide

• Length: 207 bp

>T135440 NZ_CP042341:856857-857063 [Staphylococcus capitis]
ATGGAAAATGGAATTGTTTATGTTGCTAATATTGAGACTATAGAGGAAGAAAACCAATTAAAGACACGTTTAGAAAATAT
GATTGGTGTCGAAAAAGTAGATATTGATAGTAAAGTAGGAGAAATAAAGGTATTATTTGAAACACCTGCGAATTTAAATA
GTATTGAAAAAGAAGTATATAATTCTGGCTTTCGCGTGCGTTATTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11065.56 Da
• Isoelectric Point: 6.4776

>AT135440 WP_002435858.1 NZ_CP042341:856549-856842 [Staphylococcus capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT135440 NZ_CP042341:856549-856842 [Staphylococcus capitis]
GTGACTGAAAATGAAACTGCACATCACTCAGAGCAAACGAAAGCAAATTTAAAGTCACGATTAAATCGTATCGAAGGTCA
AGTACGTGCAATTAATCGAATGATTGAAGACGATGTGTATTGCGATGATGTTTTAACTCAAATAAGAGCGACACGCTCTG
CTTTAAACAGTGTGGCTACTAAATTGTTAGATCATCATATGAAAAGTTGTATTATGAATAAAGTGAATAATGGTGCACAA
GAAGAAGCGATGGAAGAACTATTGGTTACTTTTCAAAAATTAATTAAAGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1J4E888