Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2180559..2181213 Replicon chromosome
Accession NZ_CP042336
Organism Escherichia coli strain GZ04-0086

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag E3B71_RS12765 Protein ID WP_000244772.1
Coordinates 2180559..2180966 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag E3B71_RS12770 Protein ID WP_000354046.1
Coordinates 2180947..2181213 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3B71_RS12745 2176516..2178249 - 1734 WP_000813220.1 single-stranded-DNA-specific exonuclease RecJ -
E3B71_RS12750 2178255..2178965 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E3B71_RS12755 2178990..2179886 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
E3B71_RS12760 2179998..2180519 + 522 WP_001055874.1 flavodoxin FldB -
E3B71_RS12765 2180559..2180966 - 408 WP_000244772.1 protein YgfX Toxin
E3B71_RS12770 2180947..2181213 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
E3B71_RS12775 2181456..2182436 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
E3B71_RS12780 2182513..2183172 - 660 WP_000250274.1 hemolysin III family protein -
E3B71_RS12785 2183336..2183647 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
E3B71_RS12790 2183692..2185125 + 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
E3B71_RS12795 2185182..2185925 - 744 WP_000951940.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T135420 WP_000244772.1 NZ_CP042336:c2180966-2180559 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T135420 NZ_CP042336:c2180966-2180559 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT135420 WP_000354046.1 NZ_CP042336:c2181213-2180947 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT135420 NZ_CP042336:c2181213-2180947 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References