Detailed information of TA system TA135401

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2404904..2405445
• Replicon: chromosome
• Accession: NZ_CP042331
• Organism: Bosea sp. F3-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FQV39_RS11140
• Protein ID: WP_149130344.1
• Coordinates: 2405122..2405445 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FQV39_RS11135
• Protein ID: WP_149130343.1
• Coordinates: 2404904..2405125 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQV39_RS11115	2400524..2401321	-	798	WP_149133785.1	ABC transporter permease	-
FQV39_RS11120	2401605..2402774	-	1170	WP_149133786.1	ABC transporter ATP-binding protein	-
FQV39_RS11125	2402801..2403892	-	1092	WP_149133787.1	polyamine ABC transporter substrate-binding protein	-
FQV39_RS11130	2404109..2404837	+	729	WP_149133788.1	DUF3750 domain-containing protein	-
FQV39_RS11135	2404904..2405125	+	222	WP_149130343.1	antitoxin MazE family protein	Antitoxin
FQV39_RS11140	2405122..2405445	+	324	WP_149130344.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FQV39_RS11145	2405468..2406751	-	1284	WP_149130345.1	cystathionine gamma-synthase family protein	-
FQV39_RS11150	2406897..2407355	+	459	WP_149130346.1	Lrp/AsnC family transcriptional regulator	-
FQV39_RS11155	2407368..2408372	-	1005	WP_187640246.1	alpha/beta hydrolase	-
FQV39_RS11160	2408769..2409917	-	1149	WP_187640247.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-103)

Antitoxin

• Antitoxin MazE-like (7-69)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11511.65 Da
• Isoelectric Point: 10.7342

>T135401 WP_149130344.1 NZ_CP042331:2405122-2405445 [Bosea sp. F3-2]
MKRGDLVTVAIAGDFGKPRPALIIQADPFELTATVTVLLISSNLVDAPLIRLTVKPDAANGLRLASQIMIDKAMTVRRDR
IGQVFGRLDPETMIAVNRSLALFLGLG

Nucleotide

• Length: 324 bp

>T135401 NZ_CP042331:2405122-2405445 [Bosea sp. F3-2]
ATGAAGCGCGGCGATCTCGTCACGGTCGCGATCGCCGGAGACTTCGGCAAGCCCCGCCCTGCCCTGATCATTCAGGCTGA
TCCGTTCGAGCTGACGGCGACGGTCACCGTGCTGCTGATCTCCAGCAATCTCGTCGACGCGCCATTGATCAGGCTGACGG
TCAAGCCCGACGCTGCGAACGGGCTGCGCCTTGCGTCCCAGATCATGATCGACAAGGCGATGACTGTGCGTCGGGACCGG
ATCGGCCAGGTTTTTGGCCGGCTCGATCCCGAAACGATGATCGCGGTGAACCGCTCGCTGGCGCTGTTCCTCGGCCTCGG
CTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8306.39 Da
• Isoelectric Point: 7.9992

>AT135401 WP_149130343.1 NZ_CP042331:2404904-2405125 [Bosea sp. F3-2]
MPTSTARRVQKRRDALRAAGLRPVQIWVPDTRRAGFIEECRRQARLVAVSDSADRELDTFLDAALEDLDRAPE

Nucleotide

• Length: 222 bp

>AT135401 NZ_CP042331:2404904-2405125 [Bosea sp. F3-2]
ATGCCCACTTCGACTGCCAGACGCGTTCAGAAGCGCCGCGACGCCCTGCGAGCGGCCGGGCTACGGCCGGTGCAGATCTG
GGTTCCCGACACGCGACGGGCCGGCTTCATTGAAGAGTGCCGCCGTCAGGCACGCCTCGTCGCTGTCAGCGACAGCGCCG
ATCGAGAGCTGGACACATTCCTCGACGCTGCTCTGGAAGATCTGGACCGCGCTCCTGAATGA