135397

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2918142..2919190 Replicon chromosome
Accession NZ_CP042326
Organism Euhalothece natronophila Z-M001

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag FRE64_RS14390 Protein ID WP_146296863.1
Coordinates 2918618..2919190 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag FRE64_RS14385 Protein ID WP_146296862.1
Coordinates 2918142..2918612 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRE64_RS14360 2913458..2915455 + 1998 WP_146296858.1 excinuclease ABC subunit UvrB -
FRE64_RS14365 2915644..2916063 + 420 WP_146297377.1 hypothetical protein -
FRE64_RS14370 2916120..2917400 + 1281 WP_146296859.1 ATP-binding protein -
FRE64_RS14375 2917389..2917724 - 336 WP_146296860.1 type II toxin-antitoxin system PemK/MazF family toxin -
FRE64_RS14380 2917711..2917935 - 225 WP_146296861.1 type II toxin-antitoxin system ParD family antitoxin -
FRE64_RS14385 2918142..2918612 + 471 WP_146296862.1 helix-turn-helix domain-containing protein Antitoxin
FRE64_RS14390 2918618..2919190 + 573 WP_146296863.1 PIN domain-containing protein Toxin
FRE64_RS14395 2919210..2919428 - 219 Protein_2842 hypothetical protein -
FRE64_RS14400 2919371..2919580 - 210 WP_186708854.1 IS1 family transposase -
FRE64_RS14405 2919609..2919872 - 264 WP_186708856.1 hypothetical protein -
FRE64_RS14410 2919962..2920429 - 468 WP_146296865.1 chemotaxis protein CheW -
FRE64_RS14415 2920526..2920825 - 300 WP_146296866.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
FRE64_RS14420 2921122..2921964 + 843 WP_146296867.1 M20/M25/M40 family metallo-hydrolase -
FRE64_RS14425 2922061..2923188 + 1128 WP_146296868.1 quinone-dependent dihydroorotate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Helix-turn-helix domain, group 17

(85-131)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 22133.66 Da        Isoelectric Point: 6.2275

>T135397 WP_146296863.1 NZ_CP042326:2918618-2919190 [Euhalothece natronophila Z-M001]
MPSSLTVLYDASVLYPAPLRDLLMQLALTDLYRARWTEQIHEEWIRNLLKNRPDLTRTQLNHTRQLMNRHVPDCLIKNYE
ELIPALTLPDPDDRHVLAAAIKGEVDVIVTMNLRDFPASVLTRYEMEAQHPDDFIIDLIDLDFYAVVEAVKACHARLKNP
PKSVDEYLYILTKQQLAVSVSRLRKLWFQV

Download         Length: 573 bp

>T135397 NZ_CP042326:2918618-2919190 [Euhalothece natronophila Z-M001]
ATGCCCTCATCTTTGACTGTTTTGTATGATGCCAGCGTTCTCTATCCTGCTCCCTTACGAGATTTACTCATGCAGTTGGC
GCTTACAGATCTCTATCGCGCCCGTTGGACAGAACAAATCCATGAAGAATGGATAAGAAACCTTTTAAAGAATCGTCCCG
ATTTAACCCGAACCCAACTCAATCATACTCGTCAGTTGATGAATCGTCATGTTCCAGATTGTCTCATTAAAAACTATGAG
GAGTTAATCCCAGCACTCACTTTACCCGATCCTGATGATCGCCATGTTTTAGCAGCAGCCATCAAAGGAGAGGTTGATGT
CATTGTGACCATGAACTTAAGGGATTTTCCAGCTTCTGTACTCACTCGATATGAAATGGAAGCACAGCATCCTGATGACT
TTATTATAGATTTAATTGACTTAGATTTTTATGCAGTCGTGGAAGCGGTTAAAGCCTGCCATGCCCGTCTCAAAAATCCT
CCCAAATCCGTTGACGAGTATCTTTACATTCTCACCAAACAGCAACTTGCTGTCAGTGTTTCCCGACTACGCAAATTATG
GTTTCAAGTTTAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17346.63 Da        Isoelectric Point: 5.5566

>AT135397 WP_146296862.1 NZ_CP042326:2918142-2918612 [Euhalothece natronophila Z-M001]
MSLPTESIPHRLPSESETQLSQQSSRTLAAHLPQNGTTRTFKIVDDNGEENAIELPASALHLLTEMLSQMAQGNAVTVVP
IPAELTTQEAANLLNVSRPHLVKLLEAGEIPFHKVGTHRRVRFEDLMRYKENINQKRMEALDELTAQAQALNLGYD

Download         Length: 471 bp

>AT135397 NZ_CP042326:2918142-2918612 [Euhalothece natronophila Z-M001]
ATGTCTCTTCCCACAGAATCTATTCCACACCGCTTACCTTCTGAATCGGAAACTCAACTCTCCCAACAAAGTAGCCGTAC
TTTAGCCGCTCACCTACCCCAGAACGGAACAACACGCACCTTTAAAATCGTGGATGATAACGGGGAAGAAAACGCGATCG
AGCTTCCTGCTTCAGCTCTTCATTTGCTCACAGAGATGCTTAGTCAAATGGCTCAAGGGAATGCGGTTACGGTTGTTCCC
ATTCCTGCTGAACTAACCACCCAAGAAGCTGCCAACCTGCTCAATGTTTCGCGTCCCCATTTGGTGAAACTCCTAGAAGC
GGGTGAAATCCCTTTTCACAAGGTGGGCACTCATCGTCGGGTTCGTTTTGAGGATTTGATGCGGTATAAGGAAAATATCA
ATCAAAAACGGATGGAAGCCCTTGATGAACTGACAGCACAAGCCCAAGCATTAAATCTGGGCTACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References