Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2918142..2919190 Replicon chromosome
Accession NZ_CP042326
Organism Euhalothece natronophila Z-M001

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag FRE64_RS14390 Protein ID WP_146296863.1
Coordinates 2918618..2919190 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag FRE64_RS14385 Protein ID WP_146296862.1
Coordinates 2918142..2918612 (+) Length 157 a.a.

Genomic Context

FRE64_RS14360FRE64_RS14365FRE64_RS14370FRE64_RS14385FRE64_RS14390FRE64_RS14420FRE64_RS14425FRE64_RS14375FRE64_RS14380FRE64_RS14395FRE64_RS14400FRE64_RS14405FRE64_RS14410FRE64_RS14415
Location: 2913458..2915455 (1998 bp)
Type: Others
Protein ID: WP_146296858.1
Location: 2915644..2916063 (420 bp)
Type: Others
Protein ID: WP_146297377.1
Location: 2916120..2917400 (1281 bp)
Type: Others
Protein ID: WP_146296859.1
Location: 2918142..2918612 (471 bp)
Type: Antitoxin
Protein ID: WP_146296862.1
Location: 2918618..2919190 (573 bp)
Type: Toxin
Protein ID: WP_146296863.1
Location: 2921122..2921964 (843 bp)
Type: Others
Protein ID: WP_146296867.1
Location: 2922061..2923188 (1128 bp)
Type: Others
Protein ID: WP_146296868.1
Location: 2917389..2917724 (336 bp)
Type: Others
Protein ID: WP_146296860.1
Location: 2917711..2917935 (225 bp)
Type: Others
Protein ID: WP_146296861.1
Location: 2919210..2919428 (219 bp)
Type: Others
Protein ID: Protein_2842
Location: 2919371..2919580 (210 bp)
Type: Others
Protein ID: WP_186708854.1
Location: 2919609..2919872 (264 bp)
Type: Others
Protein ID: WP_186708856.1
Location: 2919962..2920429 (468 bp)
Type: Others
Protein ID: WP_146296865.1
Location: 2920526..2920825 (300 bp)
Type: Others
Protein ID: WP_146296866.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FRE64_RS143602913458..2915455+1998WP_146296858.1excinuclease ABC subunit UvrB-
FRE64_RS143652915644..2916063+420WP_146297377.1hypothetical protein-
FRE64_RS143702916120..2917400+1281WP_146296859.1ATP-binding protein-
FRE64_RS143752917389..2917724-336WP_146296860.1type II toxin-antitoxin system PemK/MazF family toxin-
FRE64_RS143802917711..2917935-225WP_146296861.1type II toxin-antitoxin system ParD family antitoxin-
FRE64_RS143852918142..2918612+471WP_146296862.1helix-turn-helix domain-containing proteinAntitoxin
FRE64_RS143902918618..2919190+573WP_146296863.1PIN domain-containing proteinToxin
FRE64_RS143952919210..2919428-219Protein_2842hypothetical protein-
FRE64_RS144002919371..2919580-210WP_186708854.1IS1 family transposase-
FRE64_RS144052919609..2919872-264WP_186708856.1hypothetical protein-
FRE64_RS144102919962..2920429-468WP_146296865.1chemotaxis protein CheW-
FRE64_RS144152920526..2920825-300WP_146296866.12Fe-2S iron-sulfur cluster binding domain-containing protein-
FRE64_RS144202921122..2921964+843WP_146296867.1M20/M25/M40 family metallo-hydrolase-
FRE64_RS144252922061..2923188+1128WP_146296868.1quinone-dependent dihydroorotate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Helix-turn-helix domain, group 17

(85-131)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 22133.66 Da        Isoelectric Point: 6.2275

>T135397 WP_146296863.1 NZ_CP042326:2918618-2919190 [Euhalothece natronophila Z-M001]
MPSSLTVLYDASVLYPAPLRDLLMQLALTDLYRARWTEQIHEEWIRNLLKNRPDLTRTQLNHTRQLMNRHVPDCLIKNYE
ELIPALTLPDPDDRHVLAAAIKGEVDVIVTMNLRDFPASVLTRYEMEAQHPDDFIIDLIDLDFYAVVEAVKACHARLKNP
PKSVDEYLYILTKQQLAVSVSRLRKLWFQV

Download         Length: 573 bp

>T135397 NZ_CP042326:2918618-2919190 [Euhalothece natronophila Z-M001]
ATGCCCTCATCTTTGACTGTTTTGTATGATGCCAGCGTTCTCTATCCTGCTCCCTTACGAGATTTACTCATGCAGTTGGC
GCTTACAGATCTCTATCGCGCCCGTTGGACAGAACAAATCCATGAAGAATGGATAAGAAACCTTTTAAAGAATCGTCCCG
ATTTAACCCGAACCCAACTCAATCATACTCGTCAGTTGATGAATCGTCATGTTCCAGATTGTCTCATTAAAAACTATGAG
GAGTTAATCCCAGCACTCACTTTACCCGATCCTGATGATCGCCATGTTTTAGCAGCAGCCATCAAAGGAGAGGTTGATGT
CATTGTGACCATGAACTTAAGGGATTTTCCAGCTTCTGTACTCACTCGATATGAAATGGAAGCACAGCATCCTGATGACT
TTATTATAGATTTAATTGACTTAGATTTTTATGCAGTCGTGGAAGCGGTTAAAGCCTGCCATGCCCGTCTCAAAAATCCT
CCCAAATCCGTTGACGAGTATCTTTACATTCTCACCAAACAGCAACTTGCTGTCAGTGTTTCCCGACTACGCAAATTATG
GTTTCAAGTTTAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17346.63 Da        Isoelectric Point: 5.5566

>AT135397 WP_146296862.1 NZ_CP042326:2918142-2918612 [Euhalothece natronophila Z-M001]
MSLPTESIPHRLPSESETQLSQQSSRTLAAHLPQNGTTRTFKIVDDNGEENAIELPASALHLLTEMLSQMAQGNAVTVVP
IPAELTTQEAANLLNVSRPHLVKLLEAGEIPFHKVGTHRRVRFEDLMRYKENINQKRMEALDELTAQAQALNLGYD

Download         Length: 471 bp

>AT135397 NZ_CP042326:2918142-2918612 [Euhalothece natronophila Z-M001]
ATGTCTCTTCCCACAGAATCTATTCCACACCGCTTACCTTCTGAATCGGAAACTCAACTCTCCCAACAAAGTAGCCGTAC
TTTAGCCGCTCACCTACCCCAGAACGGAACAACACGCACCTTTAAAATCGTGGATGATAACGGGGAAGAAAACGCGATCG
AGCTTCCTGCTTCAGCTCTTCATTTGCTCACAGAGATGCTTAGTCAAATGGCTCAAGGGAATGCGGTTACGGTTGTTCCC
ATTCCTGCTGAACTAACCACCCAAGAAGCTGCCAACCTGCTCAATGTTTCGCGTCCCCATTTGGTGAAACTCCTAGAAGC
GGGTGAAATCCCTTTTCACAAGGTGGGCACTCATCGTCGGGTTCGTTTTGAGGATTTGATGCGGTATAAGGAAAATATCA
ATCAAAAACGGATGGAAGCCCTTGATGAACTGACAGCACAAGCCCAAGCATTAAATCTGGGCTACGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References