135380

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1699387..1699903 Replicon chromosome
Accession NZ_CP042321
Organism Klebsiella pneumoniae strain 1-16

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FRX36_RS08390 Protein ID WP_002886902.1
Coordinates 1699619..1699903 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FRX36_RS08385 Protein ID WP_002886901.1
Coordinates 1699387..1699629 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRX36_RS08370 1695416..1696156 + 741 WP_002886899.1 KDGP aldolase family protein -
FRX36_RS08375 1696222..1697376 + 1155 WP_002886900.1 lactonase family protein -
FRX36_RS08380 1697399..1699309 + 1911 WP_004152270.1 BglG family transcription antiterminator -
FRX36_RS08385 1699387..1699629 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FRX36_RS08390 1699619..1699903 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FRX36_RS08395 1699907..1700371 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FRX36_RS08400 1700612..1702750 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
FRX36_RS08405 1703107..1703850 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FRX36_RS08410 1703853..1704026 - 174 WP_002886906.1 hypothetical protein -
FRX36_RS08415 1704111..1704419 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T135380 WP_002886902.1 NZ_CP042321:1699619-1699903 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T135380 NZ_CP042321:1699619-1699903 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT135380 WP_002886901.1 NZ_CP042321:1699387-1699629 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT135380 NZ_CP042321:1699387-1699629 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References