Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 270571..271228 Replicon chromosome
Accession NZ_CP042314
Organism Klebsiella pneumoniae strain 90-17

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FLM34_RS01325 Protein ID WP_002916310.1
Coordinates 270571..270981 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FLM34_RS01330 Protein ID WP_002916312.1
Coordinates 270962..271228 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLM34_RS01305 266571..268304 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
FLM34_RS01310 268310..269023 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FLM34_RS01315 269046..269942 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FLM34_RS01320 270043..270564 + 522 WP_002916308.1 flavodoxin FldB -
FLM34_RS01325 270571..270981 - 411 WP_002916310.1 protein YgfX Toxin
FLM34_RS01330 270962..271228 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FLM34_RS01335 271474..272457 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
FLM34_RS01340 272608..273267 - 660 WP_179373097.1 hemolysin III family protein -
FLM34_RS01345 273431..273742 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
FLM34_RS01350 273792..274520 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FLM34_RS01355 274639..276072 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T135276 WP_002916310.1 NZ_CP042314:c270981-270571 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T135276 NZ_CP042314:c270981-270571 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT135276 WP_002916312.1 NZ_CP042314:c271228-270962 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT135276 NZ_CP042314:c271228-270962 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References