Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2400594..2401213 Replicon chromosome
Accession NZ_CP042311
Organism Klebsiella pneumoniae strain 101-17

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FLM38_RS11750 Protein ID WP_002892050.1
Coordinates 2400594..2400812 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FLM38_RS11755 Protein ID WP_002892066.1
Coordinates 2400839..2401213 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLM38_RS11715 2396641..2396904 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
FLM38_RS11720 2396904..2397044 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FLM38_RS11725 2397041..2397739 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
FLM38_RS11730 2397840..2399291 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
FLM38_RS11735 2399266..2399736 - 471 WP_002892026.1 YlaC family protein -
FLM38_RS11740 2399757..2399897 + 141 WP_004147370.1 hypothetical protein -
FLM38_RS11745 2399869..2400435 - 567 WP_002892030.1 maltose O-acetyltransferase -
FLM38_RS11750 2400594..2400812 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FLM38_RS11755 2400839..2401213 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FLM38_RS11760 2401699..2404845 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FLM38_RS11765 2404868..2406061 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T135266 WP_002892050.1 NZ_CP042311:c2400812-2400594 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T135266 NZ_CP042311:c2400812-2400594 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT135266 WP_002892066.1 NZ_CP042311:c2401213-2400839 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT135266 NZ_CP042311:c2401213-2400839 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References