Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1704072..1704588 Replicon chromosome
Accession NZ_CP042309
Organism Klebsiella pneumoniae strain 109-17

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FLM40_RS08405 Protein ID WP_002886902.1
Coordinates 1704304..1704588 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FLM40_RS08400 Protein ID WP_002886901.1
Coordinates 1704072..1704314 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLM40_RS08385 1700101..1700841 + 741 WP_002886899.1 KDGP aldolase family protein -
FLM40_RS08390 1700907..1702061 + 1155 WP_002886900.1 lactonase family protein -
FLM40_RS08395 1702084..1703994 + 1911 WP_004152270.1 BglG family transcription antiterminator -
FLM40_RS08400 1704072..1704314 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FLM40_RS08405 1704304..1704588 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FLM40_RS08410 1704592..1705056 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FLM40_RS08415 1705297..1707435 - 2139 WP_179373772.1 anaerobic ribonucleoside-triphosphate reductase -
FLM40_RS08420 1707792..1708535 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FLM40_RS08425 1708538..1708711 - 174 WP_002886906.1 hypothetical protein -
FLM40_RS08430 1708796..1709104 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T135228 WP_002886902.1 NZ_CP042309:1704304-1704588 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T135228 NZ_CP042309:1704304-1704588 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT135228 WP_002886901.1 NZ_CP042309:1704072-1704314 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT135228 NZ_CP042309:1704072-1704314 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References