Detailed information of TA system TA135221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 501933..502483
• Replicon: chromosome
• Accession: NZ_CP042306
• Organism: Sphingomonas panacisoli strain HKS19

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FPZ24_RS02480
• Protein ID: WP_146569564.1
• Coordinates: 501933..502253 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FPZ24_RS02485
• Protein ID: WP_205012856.1
• Coordinates: 502250..502483 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ24_RS02445	497242..498147	+	906	WP_146569558.1	Hsp33 family molecular chaperone HslO	-
FPZ24_RS02450	498237..498602	+	366	WP_146569559.1	hypothetical protein	-
FPZ24_RS02455	498772..499461	+	690	WP_146569560.1	7-cyano-7-deazaguanine synthase QueC	-
FPZ24_RS02460	499458..500099	+	642	WP_146569561.1	7-carboxy-7-deazaguanine synthase	-
FPZ24_RS02465	500104..500775	-	672	WP_186728993.1	hypothetical protein	-
FPZ24_RS02470	500950..501189	-	240	WP_146569562.1	hypothetical protein	-
FPZ24_RS02475	501280..501936	-	657	WP_146569563.1	lipoyl(octanoyl) transferase LipB	-
FPZ24_RS02480	501933..502253	-	321	WP_146569564.1	DUF5615 family PIN-like protein	Toxin
FPZ24_RS02485	502250..502483	-	234	WP_205012856.1	DUF433 domain-containing protein	Antitoxin
FPZ24_RS02490	502555..503376	+	822	WP_146569565.1	hypothetical protein	-
FPZ24_RS02495	503373..504140	+	768	WP_146569566.1	hypothetical protein	-
FPZ24_RS02500	504127..504969	-	843	WP_146569567.1	oxygen-dependent coproporphyrinogen oxidase	-
FPZ24_RS02505	504966..505415	-	450	WP_146569568.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
FPZ24_RS02510	505559..506131	+	573	WP_146569569.1	ubiquinol-cytochrome c reductase iron-sulfur subunit	-
FPZ24_RS02515	506146..507420	+	1275	WP_146569570.1	cytochrome b N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-74)

Antitoxin

• Protein of unknown function DUF433 (9-64)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12120.04 Da
• Isoelectric Point: 4.8432

>T135221 WP_146569564.1 NZ_CP042306:c502253-501933 [Sphingomonas panacisoli]
MKFLVDAQLPPALCSWLRDQGHVAMHVADIGMLAASDSEIALRAETDNAILISKDEDFLTLRLPDRFGFLWMRCGNATNR
ALLAWLDPRWEQIERLLATERLVEVR

Nucleotide

• Length: 321 bp

>T135221 NZ_CP042306:c502253-501933 [Sphingomonas panacisoli]
ATGAAATTCCTGGTCGATGCGCAGTTGCCGCCCGCTCTGTGTTCCTGGCTGCGAGATCAAGGACATGTGGCCATGCATGT
CGCCGACATCGGTATGCTCGCCGCCAGCGATAGCGAGATCGCGCTCAGGGCCGAGACCGACAATGCCATCCTGATCAGCA
AGGATGAGGATTTCCTGACTCTACGGTTGCCGGATCGGTTCGGCTTTCTTTGGATGCGATGCGGAAACGCGACCAATCGC
GCATTGCTCGCATGGCTCGATCCGCGCTGGGAACAGATCGAACGCTTGCTCGCGACCGAGCGGCTCGTGGAAGTTCGATG
A

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8009.12 Da
• Isoelectric Point: 4.3791

>AT135221 WP_205012856.1 NZ_CP042306:c502483-502250 [Sphingomonas panacisoli]
MTLAGFPRIAVDPQICGGRPVVAGTRVRVTDVLEMLAGGATADEITADFPYVSHEDVRAVLTYAAAQADHAVVLAAE

Nucleotide

• Length: 234 bp

>AT135221 NZ_CP042306:c502483-502250 [Sphingomonas panacisoli]
ATGACGTTGGCAGGCTTTCCGCGCATCGCTGTCGATCCGCAAATCTGCGGCGGCCGTCCGGTCGTCGCGGGTACACGGGT
TCGCGTCACCGATGTACTCGAAATGCTCGCGGGTGGTGCGACGGCCGACGAGATCACGGCCGATTTCCCGTACGTGAGCC
ACGAAGACGTTCGGGCCGTCTTGACCTACGCGGCCGCCCAGGCCGACCACGCGGTGGTGCTCGCCGCCGAATGA