Detailed information of TA system TA135219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-AbkA/BrnT-BrnA
• Location: 3540818..3541421
• Replicon: chromosome
• Accession: NZ_CP042304
• Organism: Devosia ginsengisoli strain Gsoil 520

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: FPZ08_RS17375
• Protein ID: WP_146291313.1
• Coordinates: 3541131..3541421 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: AbkA
• Uniprot ID: -
• Locus tag: FPZ08_RS17370
• Protein ID: WP_146293257.1
• Coordinates: 3540818..3541129 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ08_RS17340	3536214..3537035	-	822	WP_146291301.1	tryptophan synthase subunit alpha	-
FPZ08_RS17345	3537038..3538249	-	1212	WP_146291303.1	tryptophan synthase subunit beta	-
FPZ08_RS17350	3538368..3539015	-	648	WP_146291305.1	phosphoribosylanthranilate isomerase	-
FPZ08_RS17355	3539024..3539386	-	363	WP_146291307.1	DUF1049 domain-containing protein	-
FPZ08_RS17360	3539478..3539759	-	282	WP_146291309.1	integration host factor subunit beta	-
FPZ08_RS17365	3539798..3540757	-	960	WP_186767062.1	signal peptide peptidase SppA	-
FPZ08_RS17370	3540818..3541129	-	312	WP_146293257.1	BrnA antitoxin family protein	Antitoxin
FPZ08_RS17375	3541131..3541421	-	291	WP_146291313.1	BrnT family toxin	Toxin
FPZ08_RS17380	3541468..3541971	-	504	WP_146291315.1	GNAT family N-acetyltransferase	-
FPZ08_RS17385	3542068..3543771	-	1704	WP_146291317.1	30S ribosomal protein S1	-
FPZ08_RS17390	3543938..3544579	-	642	WP_146291319.1	(d)CMP kinase	-
FPZ08_RS17395	3544582..3545955	-	1374	WP_146291321.1	3-phosphoshikimate 1-carboxyvinyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-87)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (32-91)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11233.57 Da
• Isoelectric Point: 5.2417

>T135219 WP_146291313.1 NZ_CP042304:c3541421-3541131 [Devosia ginsengisoli]
VEYEWNEEKHQANIAKHKVYFEDAIEVFDDPNELTEPARTVSGEERLQTIGAVPFLATLLVVHTLRETIQGEVVTRIISA
RPASRKERQRYEQRER

Nucleotide

• Length: 291 bp

>T135219 NZ_CP042304:c3541421-3541131 [Devosia ginsengisoli]
GTGGAGTACGAATGGAACGAAGAGAAGCACCAAGCCAATATCGCCAAGCACAAGGTGTATTTCGAGGACGCGATCGAGGT
TTTCGACGACCCCAATGAACTGACCGAGCCGGCTCGCACGGTCAGTGGGGAAGAACGGCTCCAGACTATTGGCGCGGTGC
CCTTTCTGGCCACCCTGCTGGTCGTTCATACGCTGCGAGAAACAATCCAAGGCGAAGTGGTGACGCGGATCATATCCGCC
AGGCCCGCATCTCGGAAGGAAAGACAACGCTATGAGCAACGAGAACGCTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12018.80 Da
• Isoelectric Point: 10.2995

>AT135219 WP_146293257.1 NZ_CP042304:c3541129-3540818 [Devosia ginsengisoli]
MVRYTRKPLTQEQIDRLKALSERPDSEIDYSDIPPLTDEFFKNAKQGMMYRLVKQQTTLRLDADILDWFKRHAKNGKGYQ
TDINKALRAYVVAQDKKAARKAG

Nucleotide

• Length: 312 bp

>AT135219 NZ_CP042304:c3541129-3540818 [Devosia ginsengisoli]
ATGGTGCGCTATACGCGCAAGCCACTGACGCAGGAGCAGATCGATCGCCTGAAGGCCCTGTCGGAAAGGCCGGACAGCGA
AATCGACTATTCCGACATACCGCCGCTGACCGATGAGTTCTTCAAAAACGCCAAGCAGGGCATGATGTATCGGCTGGTGA
AGCAGCAGACGACTTTGCGCCTCGATGCCGACATTCTCGACTGGTTCAAGCGCCATGCCAAGAATGGCAAGGGCTACCAG
ACCGACATCAACAAGGCGCTGCGTGCTTATGTCGTGGCGCAGGACAAGAAGGCGGCCCGCAAGGCCGGGTAA