Detailed information of TA system TA135217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 651781..652376
• Replicon: chromosome
• Accession: NZ_CP042304
• Organism: Devosia ginsengisoli strain Gsoil 520

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: FPZ08_RS03225
• Protein ID: WP_146288645.1
• Coordinates: 652044..652376 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: FPZ08_RS03220
• Protein ID: WP_146292913.1
• Coordinates: 651781..652041 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ08_RS03200	647490..648602	+	1113	WP_146288643.1	endolytic transglycosylase MltG	-
FPZ08_RS03205	648620..649492	+	873	WP_146292908.1	YicC family protein	-
FPZ08_RS03210	649527..650141	+	615	WP_146292911.1	guanylate kinase	-
FPZ08_RS03215	650419..651648	+	1230	WP_146288644.1	MFS transporter	-
FPZ08_RS03220	651781..652041	+	261	WP_146292913.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FPZ08_RS03225	652044..652376	+	333	WP_146288645.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FPZ08_RS03230	652394..653236	-	843	WP_146288646.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
FPZ08_RS03235	653233..654231	-	999	WP_146288647.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
FPZ08_RS03240	654279..655178	-	900	WP_186767192.1	SurA N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-107)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11664.52 Da
• Isoelectric Point: 7.8591

>T135217 WP_146288645.1 NZ_CP042304:652044-652376 [Devosia ginsengisoli]
MERGEIWHCDLSPAAGREQKGPHYVLIVSPRAFNKGGVPLVCPITTVGNYSRMRGFAVNLSGAGTGVTGVIQVDQLSALD
MIARKGKPSGDVVPDFIMEDVLAKIATIAQ

Nucleotide

• Length: 333 bp

>T135217 NZ_CP042304:652044-652376 [Devosia ginsengisoli]
ATGGAGCGAGGGGAGATATGGCATTGCGACTTGTCACCGGCCGCCGGCCGCGAGCAGAAGGGTCCGCACTATGTGCTGAT
CGTGTCGCCTCGGGCCTTTAACAAGGGCGGTGTACCTCTGGTCTGTCCGATAACCACCGTCGGGAATTATAGCCGTATGA
GGGGCTTTGCTGTGAACCTCTCTGGTGCCGGCACTGGCGTAACCGGCGTTATCCAGGTGGACCAGTTGAGTGCATTGGAC
ATGATTGCACGCAAGGGCAAGCCCTCGGGTGATGTGGTCCCTGACTTTATCATGGAAGATGTCTTGGCGAAGATTGCCAC
GATAGCGCAATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9641.06 Da
• Isoelectric Point: 5.5751

>AT135217 WP_146292913.1 NZ_CP042304:651781-652041 [Devosia ginsengisoli]
MSHTRLKKSGGSLVMTVPAAARDTLHLHEGQELTVKVEDQKLVLEPAVRRPKYTLEELLAHCDFDAPLSEEERAWLDAPP
VGRELL

Nucleotide

• Length: 261 bp

>AT135217 NZ_CP042304:651781-652041 [Devosia ginsengisoli]
TTGAGCCATACCCGGCTCAAGAAGTCGGGCGGATCGCTGGTTATGACCGTGCCGGCAGCGGCGCGTGACACGCTGCATCT
GCACGAGGGCCAGGAATTGACCGTCAAGGTCGAAGACCAAAAGCTCGTTTTGGAACCAGCAGTGCGGCGCCCGAAATATA
CGCTTGAGGAACTGCTGGCTCATTGCGATTTCGACGCCCCCCTTAGTGAGGAAGAACGCGCCTGGCTTGACGCTCCTCCC
GTTGGTCGGGAACTCCTGTAG