Detailed information of TA system TA135216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 437772..438298
• Replicon: chromosome
• Accession: NZ_CP042304
• Organism: Devosia ginsengisoli strain Gsoil 520

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: FPZ08_RS02220
• Protein ID: WP_146288478.1
• Coordinates: 437772..438068 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: FPZ08_RS02225
• Protein ID: WP_146292867.1
• Coordinates: 438068..438298 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ08_RS02205	432865..434037	+	1173	WP_146288475.1	FAD-dependent monooxygenase	-
FPZ08_RS02210	434155..436626	+	2472	WP_186767177.1	glycoside hydrolase family 2 protein	-
FPZ08_RS02215	436858..437775	+	918	WP_146288477.1	DMT family transporter	-
FPZ08_RS02220	437772..438068	-	297	WP_146288478.1	CcdB family protein	Toxin
FPZ08_RS02225	438068..438298	-	231	WP_146292867.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
FPZ08_RS02230	438351..439634	-	1284	WP_146288479.1	NAD(P)/FAD-dependent oxidoreductase	-
FPZ08_RS02235	439706..441064	-	1359	WP_146288480.1	carbohydrate kinase	-
FPZ08_RS02240	441153..441602	-	450	WP_186767178.1	universal stress protein	-
FPZ08_RS02245	441868..442497	+	630	WP_146288482.1	Tim44/TimA family putative adaptor protein	-
FPZ08_RS02250	442490..442856	+	367	Protein_451	DUF488 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (10-97)

Antitoxin

• Post-segregation antitoxin CcdA (6-76)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10606.35 Da
• Isoelectric Point: 4.9097

>T135216 WP_146288478.1 NZ_CP042304:c438068-437772 [Devosia ginsengisoli]
MARYDVRSSADGYLYVEVQADILDQLNTRVVIPLMSLDVAPVPAGRLNPIIRVADVPLSLVTQYLAAVRASTLGPVVGSV
AHEQDRISLALDMLLKGY

Nucleotide

• Length: 297 bp

>T135216 NZ_CP042304:c438068-437772 [Devosia ginsengisoli]
ATGGCGCGGTATGATGTGCGAAGCAGCGCCGATGGCTATCTCTATGTCGAGGTGCAGGCTGATATATTGGACCAGCTCAA
CACGCGGGTCGTCATTCCCCTGATGTCGCTCGATGTCGCGCCGGTGCCGGCCGGGCGGCTCAATCCGATAATCAGGGTGG
CCGATGTACCGTTATCGCTGGTGACCCAATATCTGGCTGCCGTGCGGGCCTCCACACTTGGGCCTGTTGTCGGTTCGGTA
GCTCACGAACAAGACAGAATAAGCCTCGCGCTCGATATGCTGCTGAAGGGCTATTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8724.78 Da
• Isoelectric Point: 6.3629

>AT135216 WP_146292867.1 NZ_CP042304:c438298-438068 [Devosia ginsengisoli]
MRATARKPTNLTLDSELVSEARALNINVSRAAENGLEAAIRKERERRWLEENAEAIQSSNDWVEKNGLPLEKYRPF

Nucleotide

• Length: 231 bp

>AT135216 NZ_CP042304:c438298-438068 [Devosia ginsengisoli]
ATGAGAGCCACAGCACGAAAGCCGACGAACCTGACGCTTGATTCAGAGCTGGTCTCCGAGGCGCGCGCACTCAACATCAA
TGTATCGCGGGCGGCGGAGAACGGCCTTGAAGCGGCCATACGCAAGGAGCGTGAGCGGCGGTGGCTGGAAGAGAATGCCG
AGGCCATCCAGAGCTCCAATGACTGGGTGGAGAAGAACGGGCTGCCCCTGGAAAAATATCGGCCGTTCTGA