Detailed information of TA system TA135214

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 186556..187102
• Replicon: chromosome
• Accession: NZ_CP042304
• Organism: Devosia ginsengisoli strain Gsoil 520

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FPZ08_RS00980
• Protein ID: WP_146288253.1
• Coordinates: 186556..186879 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FPZ08_RS00985
• Protein ID: WP_146288254.1
• Coordinates: 186866..187102 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ08_RS00965	183078..184568	+	1491	WP_146288250.1	DHA2 family efflux MFS transporter permease subunit	-
FPZ08_RS00970	184631..185167	-	537	WP_146288251.1	molybdenum cofactor biosynthesis protein B	-
FPZ08_RS00975	185145..186470	-	1326	WP_146288252.1	MFS transporter	-
FPZ08_RS00980	186556..186879	-	324	WP_146288253.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FPZ08_RS00985	186866..187102	-	237	WP_146288254.1	antitoxin MazE family protein	Antitoxin
FPZ08_RS00990	187147..187956	-	810	WP_146288255.1	uracil-DNA glycosylase	-
FPZ08_RS00995	188035..189681	+	1647	WP_146288256.1	electron transfer flavoprotein-ubiquinone oxidoreductase	-
FPZ08_RS01000	189789..191531	+	1743	WP_146288257.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (14-105)

Antitoxin

• Antitoxin MazE-like (7-68)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11543.54 Da
• Isoelectric Point: 9.8619

>T135214 WP_146288253.1 NZ_CP042304:c186879-186556 [Devosia ginsengisoli]
MKRSSVVKVALPGDLGKPRPALVVQSDAYDATGTVAVLPLTSDLTDITLFRVLLEPSPDNGLRHPSHVMIDKITNVRRDK
VGGVIGTLRDDIMLEITRKLAVFLGIG

Nucleotide

• Length: 324 bp

>T135214 NZ_CP042304:c186879-186556 [Devosia ginsengisoli]
ATGAAGAGGAGTAGTGTCGTCAAAGTTGCCTTGCCCGGCGACCTCGGCAAACCGCGCCCCGCGCTTGTCGTCCAGTCAGA
CGCATATGATGCAACCGGGACCGTCGCGGTTTTGCCCCTGACCAGTGACCTTACCGACATTACGCTATTTCGGGTCTTGC
TGGAGCCGTCGCCGGACAATGGCCTGCGTCACCCATCGCATGTCATGATCGACAAGATTACCAATGTCCGACGCGACAAG
GTCGGCGGGGTGATCGGCACCCTGCGCGATGACATTATGCTCGAGATTACGCGCAAGCTCGCTGTGTTCCTGGGCATCGG
CTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8790.83 Da
• Isoelectric Point: 4.2092

>AT135214 WP_146288254.1 NZ_CP042304:c187102-186866 [Devosia ginsengisoli]
MVSSVSQRVQKRRDALRAQGLRPVQIWLPDVTAPGFAEEARRQSLLAAEADARDPELQSFLDAALLDLAEDWPPYEEE

Nucleotide

• Length: 237 bp

>AT135214 NZ_CP042304:c187102-186866 [Devosia ginsengisoli]
ATGGTTTCATCGGTCAGTCAGAGAGTACAGAAGCGGCGCGATGCCCTGCGGGCGCAGGGTCTTCGGCCTGTACAAATATG
GCTGCCCGACGTAACGGCACCGGGGTTTGCCGAAGAAGCTCGTCGTCAGTCGCTGCTTGCCGCCGAGGCAGATGCGCGCG
ATCCGGAGCTGCAGAGTTTCCTGGACGCGGCATTGCTGGACCTAGCCGAGGATTGGCCTCCTTATGAAGAGGAGTAG