Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3865022..3865655 Replicon chromosome
Accession NZ_CP042302
Organism Paracidovorax citrulli strain NWB SC074

Toxin (Protein)


Gene name vapC Uniprot ID A1TJP6
Locus tag FRC75_RS17825 Protein ID WP_011793755.1
Coordinates 3865022..3865435 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B0DRJ9
Locus tag FRC75_RS17830 Protein ID WP_041827216.1
Coordinates 3865422..3865655 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRC75_RS17800 (FRC75_17840) 3860029..3861066 - 1038 WP_011793760.1 anthranilate phosphoribosyltransferase -
FRC75_RS17805 (FRC75_17845) 3861099..3861782 - 684 WP_011793759.1 LysE family translocator -
FRC75_RS17810 (FRC75_17850) 3861854..3862426 - 573 WP_011793758.1 aminodeoxychorismate/anthranilate synthase component II -
FRC75_RS17815 (FRC75_17855) 3863111..3864625 + 1515 WP_011793757.1 conjugal transfer protein TraG N-terminal domain-containing protein -
FRC75_RS17820 (FRC75_17860) 3864639..3865001 - 363 WP_011793756.1 DUF3742 family protein -
FRC75_RS17825 (FRC75_17865) 3865022..3865435 - 414 WP_011793755.1 PIN domain-containing protein Toxin
FRC75_RS17830 (FRC75_17870) 3865422..3865655 - 234 WP_041827216.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3821055..3991569 170514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-119)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15147.48 Da        Isoelectric Point: 6.2136

>T135211 WP_011793755.1 NZ_CP042302:c3865435-3865022 [Paracidovorax citrulli]
MAAGKGKVFLDSNVVLYLLSEDAAKADSAEALLHRRPVISVQVLNEVTHVCVRKLKMGWGEVGQFLALVREFCSIVPLTV
EVHDRARQLAERHQLSFYDACIVAAAAAEGCQTLYSEDMHHGLIIEESLSIRNPFNV

Download         Length: 414 bp

>T135211 NZ_CP042302:c3865435-3865022 [Paracidovorax citrulli]
ATGGCCGCGGGTAAGGGCAAGGTGTTCCTCGACAGCAACGTGGTGCTCTACCTGCTGTCCGAGGACGCGGCGAAGGCGGA
CAGCGCCGAGGCGCTGCTGCATCGTCGCCCGGTCATCAGCGTCCAGGTACTCAACGAGGTCACCCACGTCTGCGTGCGCA
AGCTGAAGATGGGGTGGGGAGAGGTGGGTCAGTTCCTGGCGCTGGTGAGAGAGTTCTGCAGCATTGTTCCGCTCACAGTC
GAGGTGCACGACCGGGCCCGCCAACTGGCCGAGCGGCACCAGCTGTCGTTCTACGACGCATGCATTGTGGCGGCCGCCGC
AGCCGAAGGCTGCCAGACGCTCTACTCCGAAGACATGCACCATGGCCTCATCATCGAAGAGAGCCTGTCGATTCGTAACC
CGTTCAACGTTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8518.76 Da        Isoelectric Point: 8.7857

>AT135211 WP_041827216.1 NZ_CP042302:c3865655-3865422 [Paracidovorax citrulli]
MLVAKWGNSLAVRLPANVVEALELREGDDIEIFVGDARSFAVSKKPGAEAMLERLRTFRGKLPADFKFNRDEANGRG

Download         Length: 234 bp

>AT135211 NZ_CP042302:c3865655-3865422 [Paracidovorax citrulli]
ATGCTAGTCGCGAAGTGGGGCAATAGCTTGGCGGTTCGCCTGCCGGCGAACGTAGTCGAAGCGCTCGAACTGCGGGAAGG
CGATGACATCGAAATCTTCGTCGGTGATGCGCGATCGTTCGCGGTGAGCAAGAAGCCCGGCGCCGAGGCGATGCTGGAGC
GCCTCCGTACCTTCCGCGGCAAGCTGCCGGCGGACTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1TJP6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0DRJ9

References