135206

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 552369..552979 Replicon chromosome
Accession NZ_CP042301
Organism Nitratireductor sp. SY7

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FQ775_RS02615 Protein ID WP_146301669.1
Coordinates 552369..552623 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FQ775_RS02620 Protein ID WP_146301668.1
Coordinates 552620..552979 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQ775_RS02595 548844..549854 - 1011 WP_146301672.1 helix-turn-helix transcriptional regulator -
FQ775_RS02600 550003..550182 + 180 WP_146301671.1 hypothetical protein -
FQ775_RS02605 550217..550455 - 239 Protein_515 DUF2200 family protein -
FQ775_RS02610 550660..552267 - 1608 WP_146301670.1 methylcrotonoyl-CoA carboxylase -
FQ775_RS02615 552369..552623 + 255 WP_146301669.1 type II toxin-antitoxin system HicA family toxin Toxin
FQ775_RS02620 552620..552979 + 360 WP_146301668.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FQ775_RS02625 553004..553717 - 714 WP_146301667.1 flavodoxin family protein -
FQ775_RS02630 553816..554586 - 771 WP_146301666.1 hypothetical protein -
FQ775_RS02635 554688..555767 - 1080 WP_146301665.1 trypsin-like serine protease -
FQ775_RS02640 556038..556748 - 711 WP_206064873.1 ABC transporter permease -
FQ775_RS02645 556754..557191 - 438 WP_146301664.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9520.97 Da        Isoelectric Point: 12.0013

>T135206 WP_146301669.1 NZ_CP042301:552369-552623 [Nitratireductor sp. SY7]
MHAKHRRTLEAVFRDPVSGTIKWRDIEAMLIGLGAEISEGSGSRIRFSLRGRTLFVHRPHPSPDARRYVVRNVRQFLSEA
GIGP

Download         Length: 255 bp

>T135206 NZ_CP042301:552369-552623 [Nitratireductor sp. SY7]
ATGCATGCCAAACATCGCCGCACACTGGAAGCGGTTTTTCGCGATCCGGTCAGCGGCACGATCAAGTGGCGAGATATCGA
GGCGATGCTGATCGGACTTGGCGCTGAAATCAGCGAAGGCAGTGGATCGCGCATACGTTTTTCGCTGCGTGGCAGAACGC
TTTTCGTGCATCGGCCCCACCCTTCGCCGGACGCGCGGCGATATGTGGTGCGCAATGTGAGACAGTTTTTGAGCGAAGCG
GGAATAGGACCTTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13146.63 Da        Isoelectric Point: 4.9685

>AT135206 WP_146301668.1 NZ_CP042301:552620-552979 [Nitratireductor sp. SY7]
MRSYKGYAGTVEFEEDDLVFHGRVVGIRDLVTYEASTAEGLVKAFRDSVEDYLSFCAEQGKEPEKPFSGKLALRTTPEIH
DLVSRAAASDGKSVNQWISDTLADAASKRVEAGWTRVRS

Download         Length: 360 bp

>AT135206 NZ_CP042301:552620-552979 [Nitratireductor sp. SY7]
TTGAGATCGTACAAGGGGTATGCAGGGACCGTCGAGTTCGAGGAGGACGATCTTGTCTTCCACGGCCGGGTCGTGGGCAT
CCGTGATCTGGTGACGTATGAGGCGAGCACCGCCGAAGGTCTCGTGAAAGCGTTCCGCGACAGCGTCGAGGATTATCTTT
CCTTTTGCGCCGAACAGGGCAAGGAGCCCGAGAAGCCGTTTTCCGGCAAGCTAGCCTTGCGCACGACACCTGAAATTCAC
GACCTTGTAAGCCGCGCCGCGGCGAGCGACGGCAAGTCGGTCAATCAGTGGATTTCGGACACGCTGGCGGACGCGGCGTC
GAAACGCGTCGAGGCCGGCTGGACGCGCGTGCGCAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References