Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 888515..889093 | Replicon | chromosome |
| Accession | NZ_CP042300 | ||
| Organism | Vibrio cholerae O1 strain AAS91 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | FKV26_RS17550 | Protein ID | WP_001180243.1 |
| Coordinates | 888776..889093 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | FKV26_RS17545 | Protein ID | WP_000557292.1 |
| Coordinates | 888515..888757 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FKV26_RS17500 | 883931..884101 | - | 171 | WP_001882300.1 | DUF645 family protein | - |
| FKV26_RS19000 | 884296..884406 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| FKV26_RS17510 | 884403..884720 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| FKV26_RS17515 | 884731..885018 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FKV26_RS17520 | 885285..885465 | - | 181 | Protein_814 | DUF645 family protein | - |
| FKV26_RS17525 | 885890..886123 | - | 234 | Protein_815 | DUF3709 domain-containing protein | - |
| FKV26_RS17530 | 886526..886744 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| FKV26_RS17535 | 887054..887707 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| FKV26_RS17540 | 887764..888273 | - | 510 | WP_000405986.1 | GNAT family N-acetyltransferase | - |
| FKV26_RS17545 | 888515..888757 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FKV26_RS17550 | 888776..889093 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FKV26_RS17555 | 889108..889230 | - | 123 | WP_080033517.1 | DUF3265 domain-containing protein | - |
| FKV26_RS17560 | 889252..889470 | - | 219 | WP_001209280.1 | hypothetical protein | - |
| FKV26_RS17565 | 889713..890123 | - | 411 | WP_000734967.1 | hypothetical protein | - |
| FKV26_RS17570 | 890264..890779 | - | 516 | WP_000343781.1 | GNAT family N-acetyltransferase | - |
| FKV26_RS17575 | 890923..891372 | - | 450 | WP_001026798.1 | GyrI-like domain-containing protein | - |
| FKV26_RS17580 | 891535..891771 | - | 237 | WP_001059493.1 | hypothetical protein | - |
| FKV26_RS17585 | 892014..892514 | - | 501 | WP_000686370.1 | NAD(P)H-dependent oxidoreductase | - |
| FKV26_RS17590 | 892773..893006 | - | 234 | WP_080004228.1 | DUF3709 domain-containing protein | - |
| FKV26_RS17595 | 893278..893760 | - | 483 | WP_000422943.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 827249..947639 | 120390 | |
| - | inside | Integron | - | - | 828494..941258 | 112764 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T135205 WP_001180243.1 NZ_CP042300:888776-889093 [Vibrio cholerae O1]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T135205 NZ_CP042300:888776-889093 [Vibrio cholerae O1]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT135205 WP_000557292.1 NZ_CP042300:888515-888757 [Vibrio cholerae O1]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT135205 NZ_CP042300:888515-888757 [Vibrio cholerae O1]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |