Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 861601..862129 | Replicon | chromosome |
| Accession | NZ_CP042300 | ||
| Organism | Vibrio cholerae O1 strain AAS91 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | H9L4R3 |
| Locus tag | FKV26_RS17330 | Protein ID | WP_000221352.1 |
| Coordinates | 861839..862129 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | H9L4T4 |
| Locus tag | FKV26_RS17325 | Protein ID | WP_000213183.1 |
| Coordinates | 861601..861849 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FKV26_RS17295 | 857337..857801 | + | 465 | WP_000140244.1 | hypothetical protein | - |
| FKV26_RS17300 | 857901..858299 | - | 399 | WP_001882293.1 | hypothetical protein | - |
| FKV26_RS18970 | 858455..858955 | - | 501 | WP_000789723.1 | hypothetical protein | - |
| FKV26_RS17305 | 859093..859623 | - | 531 | WP_000415563.1 | hypothetical protein | - |
| FKV26_RS17310 | 859774..860169 | - | 396 | WP_000649527.1 | DUF3465 domain-containing protein | - |
| FKV26_RS17315 | 860377..860802 | - | 426 | WP_000415748.1 | hypothetical protein | - |
| FKV26_RS17320 | 861070..861405 | - | 336 | WP_000332173.1 | hypothetical protein | - |
| FKV26_RS17325 | 861601..861849 | + | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| FKV26_RS17330 | 861839..862129 | + | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FKV26_RS17335 | 862265..862780 | - | 516 | WP_001201532.1 | lipocalin family protein | - |
| FKV26_RS17340 | 862807..862899 | - | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| FKV26_RS18975 | 862921..863499 | - | 579 | WP_000110120.1 | hypothetical protein | - |
| FKV26_RS17345 | 863728..863970 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FKV26_RS17350 | 863967..864266 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FKV26_RS17355 | 864397..864912 | - | 516 | WP_000100089.1 | ClbS/DfsB family four-helix bundle protein | - |
| FKV26_RS17360 | 865107..865289 | - | 183 | WP_001889223.1 | DUF645 family protein | - |
| FKV26_RS17365 | 865584..866033 | - | 450 | WP_000480555.1 | hypothetical protein | - |
| FKV26_RS17370 | 866168..866707 | - | 540 | WP_000884561.1 | hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 827249..947639 | 120390 | |
| - | inside | Integron | - | - | 828494..941258 | 112764 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11247.23 Da Isoelectric Point: 10.4678
>T135201 WP_000221352.1 NZ_CP042300:861839-862129 [Vibrio cholerae O1]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD
Download Length: 291 bp
>T135201 NZ_CP042300:861839-862129 [Vibrio cholerae O1]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 8937.28 Da Isoelectric Point: 4.1079
>AT135201 WP_000213183.1 NZ_CP042300:861601-861849 [Vibrio cholerae O1]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL
Download Length: 249 bp
>AT135201 NZ_CP042300:861601-861849 [Vibrio cholerae O1]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | H9L4R3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A366A3W8 |