Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 1379996..1380474 | Replicon | chromosome |
Accession | NZ_CP042298 | ||
Organism | Escherichia coli strain RM9088 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | - |
Locus tag | FRV13_RS08255 | Protein ID | WP_047087131.1 |
Coordinates | 1379996..1380283 (-) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | A0A2A3V0Y3 |
Locus tag | FRV13_RS08260 | Protein ID | WP_000108763.1 |
Coordinates | 1380283..1380474 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FRV13_RS08225 | 1377003..1377206 | - | 204 | WP_001098749.1 | DUF1482 family protein | - |
FRV13_RS08230 | 1377209..1377391 | - | 183 | WP_000449182.1 | cell division inhibition protein DicB | - |
FRV13_RS08235 | 1377961..1378449 | + | 489 | WP_123059909.1 | hypothetical protein | - |
FRV13_RS08240 | 1378576..1378785 | + | 210 | WP_047087134.1 | hypothetical protein | - |
FRV13_RS08245 | 1378786..1379424 | - | 639 | WP_047087133.1 | hypothetical protein | - |
FRV13_RS08250 | 1379566..1379721 | - | 156 | WP_047087132.1 | DUF1391 family protein | - |
FRV13_RS08255 | 1379996..1380283 | - | 288 | WP_047087131.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FRV13_RS08260 | 1380283..1380474 | - | 192 | WP_000108763.1 | hypothetical protein | Antitoxin |
FRV13_RS08265 | 1380503..1380901 | - | 399 | WP_047087139.1 | helix-turn-helix domain-containing protein | - |
FRV13_RS08270 | 1381008..1381280 | + | 273 | WP_047087130.1 | transcriptional regulator | - |
FRV13_RS08275 | 1381264..1381689 | + | 426 | WP_042966237.1 | Rha family transcriptional regulator | - |
FRV13_RS08280 | 1381761..1382795 | + | 1035 | WP_137578463.1 | phage replisome organizer | - |
FRV13_RS08285 | 1382707..1383249 | + | 543 | WP_187270338.1 | replication protein | - |
FRV13_RS08290 | 1383284..1384054 | + | 771 | Protein_1296 | DUF1627 domain-containing protein | - |
FRV13_RS08295 | 1384070..1384492 | + | 423 | WP_040072802.1 | DUF977 family protein | - |
FRV13_RS08300 | 1384550..1384906 | + | 357 | WP_040072812.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1373030..1424064 | 51034 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10847.61 Da Isoelectric Point: 9.7196
>T135169 WP_047087131.1 NZ_CP042298:c1380283-1379996 [Escherichia coli]
MLPVLWLPSARDDLSQIITYIAKKNPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVATSSIE
IVSVIHARQQYPGND
MLPVLWLPSARDDLSQIITYIAKKNPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVATSSIE
IVSVIHARQQYPGND
Download Length: 288 bp
>T135169 NZ_CP042298:c1380283-1379996 [Escherichia coli]
ATGCTGCCCGTTTTATGGTTACCGTCTGCTCGCGATGATTTAAGTCAGATTATAACTTACATTGCTAAGAAAAACCCTCC
GGCAGCGCGCAGACTAAAAATACGCATTGAAACATCGGTGCTGCCCCTATCTGAGCATCCGTATCTATATCCGCCAAGCG
AACGGGTTTCTGGATTGAGAGAAATCGTGACTCACCCTAACTACATAATCCTATACAGGGTAGCTACTTCAAGCATTGAA
ATTGTTAGCGTGATACATGCTCGTCAGCAATATCCTGGTAACGATTAA
ATGCTGCCCGTTTTATGGTTACCGTCTGCTCGCGATGATTTAAGTCAGATTATAACTTACATTGCTAAGAAAAACCCTCC
GGCAGCGCGCAGACTAAAAATACGCATTGAAACATCGGTGCTGCCCCTATCTGAGCATCCGTATCTATATCCGCCAAGCG
AACGGGTTTCTGGATTGAGAGAAATCGTGACTCACCCTAACTACATAATCCTATACAGGGTAGCTACTTCAAGCATTGAA
ATTGTTAGCGTGATACATGCTCGTCAGCAATATCCTGGTAACGATTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7031.01 Da Isoelectric Point: 4.2690
>AT135169 WP_000108763.1 NZ_CP042298:c1380474-1380283 [Escherichia coli]
MSTVLSPIVSEFETIEQENSYNEWLRAKVAASLADPRPAIPHDEVMAKMEKIINQIAMENGSV
MSTVLSPIVSEFETIEQENSYNEWLRAKVAASLADPRPAIPHDEVMAKMEKIINQIAMENGSV
Download Length: 192 bp
>AT135169 NZ_CP042298:c1380474-1380283 [Escherichia coli]
ATGAGCACAGTTCTTTCGCCGATAGTTTCAGAATTTGAAACTATCGAGCAAGAAAACAGTTACAACGAATGGTTGCGCGC
CAAGGTTGCAGCAAGCCTTGCAGATCCACGACCAGCAATACCGCACGACGAAGTAATGGCAAAAATGGAAAAAATCATCA
ATCAAATTGCCATGGAAAACGGGAGCGTGTAA
ATGAGCACAGTTCTTTCGCCGATAGTTTCAGAATTTGAAACTATCGAGCAAGAAAACAGTTACAACGAATGGTTGCGCGC
CAAGGTTGCAGCAAGCCTTGCAGATCCACGACCAGCAATACCGCACGACGAAGTAATGGCAAAAATGGAAAAAATCATCA
ATCAAATTGCCATGGAAAACGGGAGCGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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