Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1379996..1380474 Replicon chromosome
Accession NZ_CP042298
Organism Escherichia coli strain RM9088

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag FRV13_RS08255 Protein ID WP_047087131.1
Coordinates 1379996..1380283 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A2A3V0Y3
Locus tag FRV13_RS08260 Protein ID WP_000108763.1
Coordinates 1380283..1380474 (-) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRV13_RS08225 1377003..1377206 - 204 WP_001098749.1 DUF1482 family protein -
FRV13_RS08230 1377209..1377391 - 183 WP_000449182.1 cell division inhibition protein DicB -
FRV13_RS08235 1377961..1378449 + 489 WP_123059909.1 hypothetical protein -
FRV13_RS08240 1378576..1378785 + 210 WP_047087134.1 hypothetical protein -
FRV13_RS08245 1378786..1379424 - 639 WP_047087133.1 hypothetical protein -
FRV13_RS08250 1379566..1379721 - 156 WP_047087132.1 DUF1391 family protein -
FRV13_RS08255 1379996..1380283 - 288 WP_047087131.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FRV13_RS08260 1380283..1380474 - 192 WP_000108763.1 hypothetical protein Antitoxin
FRV13_RS08265 1380503..1380901 - 399 WP_047087139.1 helix-turn-helix domain-containing protein -
FRV13_RS08270 1381008..1381280 + 273 WP_047087130.1 transcriptional regulator -
FRV13_RS08275 1381264..1381689 + 426 WP_042966237.1 Rha family transcriptional regulator -
FRV13_RS08280 1381761..1382795 + 1035 WP_137578463.1 phage replisome organizer -
FRV13_RS08285 1382707..1383249 + 543 WP_187270338.1 replication protein -
FRV13_RS08290 1383284..1384054 + 771 Protein_1296 DUF1627 domain-containing protein -
FRV13_RS08295 1384070..1384492 + 423 WP_040072802.1 DUF977 family protein -
FRV13_RS08300 1384550..1384906 + 357 WP_040072812.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1373030..1424064 51034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 10847.61 Da        Isoelectric Point: 9.7196

>T135169 WP_047087131.1 NZ_CP042298:c1380283-1379996 [Escherichia coli]
MLPVLWLPSARDDLSQIITYIAKKNPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVATSSIE
IVSVIHARQQYPGND

Download         Length: 288 bp

>T135169 NZ_CP042298:c1380283-1379996 [Escherichia coli]
ATGCTGCCCGTTTTATGGTTACCGTCTGCTCGCGATGATTTAAGTCAGATTATAACTTACATTGCTAAGAAAAACCCTCC
GGCAGCGCGCAGACTAAAAATACGCATTGAAACATCGGTGCTGCCCCTATCTGAGCATCCGTATCTATATCCGCCAAGCG
AACGGGTTTCTGGATTGAGAGAAATCGTGACTCACCCTAACTACATAATCCTATACAGGGTAGCTACTTCAAGCATTGAA
ATTGTTAGCGTGATACATGCTCGTCAGCAATATCCTGGTAACGATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7031.01 Da        Isoelectric Point: 4.2690

>AT135169 WP_000108763.1 NZ_CP042298:c1380474-1380283 [Escherichia coli]
MSTVLSPIVSEFETIEQENSYNEWLRAKVAASLADPRPAIPHDEVMAKMEKIINQIAMENGSV

Download         Length: 192 bp

>AT135169 NZ_CP042298:c1380474-1380283 [Escherichia coli]
ATGAGCACAGTTCTTTCGCCGATAGTTTCAGAATTTGAAACTATCGAGCAAGAAAACAGTTACAACGAATGGTTGCGCGC
CAAGGTTGCAGCAAGCCTTGCAGATCCACGACCAGCAATACCGCACGACGAAGTAATGGCAAAAATGGAAAAAATCATCA
ATCAAATTGCCATGGAAAACGGGAGCGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A2A3V0Y3

References