Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 112039..112561 Replicon plasmid p1RM9088
Accession NZ_CP042296
Organism Escherichia coli strain RM9088

Toxin (Protein)


Gene name relE Uniprot ID A0A2A6Q014
Locus tag FRV13_RS00620 Protein ID WP_000220564.1
Coordinates 112039..112320 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0B0W3C1
Locus tag FRV13_RS00625 Protein ID WP_000121742.1
Coordinates 112310..112561 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRV13_RS00590 107172..107468 + 297 Protein_109 IS21 family transposase -
FRV13_RS00595 107465..108247 + 783 WP_137486424.1 IS21-like element IS100kyp family helper ATPase IstB -
FRV13_RS00605 108315..108978 + 664 Protein_111 IS3 family transposase -
FRV13_RS00610 109036..110228 - 1193 Protein_112 IS256 family transposase -
FRV13_RS00615 110295..111508 + 1214 WP_169302185.1 IS3 family transposase -
FRV13_RS00620 112039..112320 - 282 WP_000220564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FRV13_RS00625 112310..112561 - 252 WP_000121742.1 hypothetical protein Antitoxin
FRV13_RS00630 112837..113856 - 1020 WP_096913040.1 IS110 family transposase -
FRV13_RS00640 114376..115485 - 1110 Protein_117 IS3 family transposase -
FRV13_RS00645 115565..115960 - 396 Protein_118 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyD / hlyD / hlyB / hlyA / hlyC / estIa / faeJ / faeI / faeH / faeF / faeE / faeD / faeC 1..167256 167256
- inside IScluster/Tn - - 103116..127426 24310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11009.78 Da        Isoelectric Point: 10.5938

>T135156 WP_000220564.1 NZ_CP042296:c112320-112039 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLSERLENPRAPAARLHGHADRYKIKLRSSGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T135156 NZ_CP042296:c112320-112039 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGTCAGAACGGCTGGAAAATCCACGCGCACCTGCAGCCCGATTACATGGTCATGCTGATCGTTATAAAATCA
AACTTCGTTCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGAGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.47 Da        Isoelectric Point: 4.2958

>AT135156 WP_000121742.1 NZ_CP042296:c112561-112310 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKKPEIVKVSL
DDL

Download         Length: 252 bp

>AT135156 NZ_CP042296:c112561-112310 [Escherichia coli]
ATGAGTTATCAAATCCTGACAACCACAGCGGCCAGTATTACTGACCTAAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCAATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAAACCGGAAATTGTGAAGGTTAGCCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6Q014

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0W3C1

References