Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2263112..2263626 Replicon chromosome
Accession NZ_CP042286
Organism Staphylococcus argenteus strain B3-25B

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag FPV14_RS10850 Protein ID WP_000233591.1
Coordinates 2263112..2263321 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag FPV14_RS10855 Protein ID WP_000138934.1
Coordinates 2263333..2263626 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPV14_RS10830 2258455..2259819 - 1365 WP_047557444.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FPV14_RS10835 2259834..2260904 - 1071 WP_000159636.1 D-alanine--D-alanine ligase -
FPV14_RS10840 2261223..2262425 + 1203 WP_001109945.1 rod shape-determining protein RodA -
FPV14_RS10845 2262846..2262983 - 138 WP_000828355.1 hypothetical protein -
FPV14_RS10850 2263112..2263321 - 210 WP_000233591.1 heavy-metal-associated domain-containing protein Toxin
FPV14_RS10855 2263333..2263626 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
FPV14_RS10860 2263794..2265278 + 1485 WP_047433078.1 cardiolipin synthase -
FPV14_RS10865 2265307..2265954 + 648 WP_047557448.1 HD domain-containing protein -
FPV14_RS10870 2266022..2266270 + 249 WP_162272146.1 hypothetical protein -
FPV14_RS10880 2266716..2267585 - 870 WP_000725805.1 membrane protein insertase YidC -
FPV14_RS10885 2267671..2268312 - 642 WP_047557451.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T135150 WP_000233591.1 NZ_CP042286:c2263321-2263112 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T135150 NZ_CP042286:c2263321-2263112 [Staphylococcus argenteus]
ATGGTACATCAAAACACAATATATACTGCAGGTATTGAAACTGAAGAACAAGTAAACCAGTTGACAGAACGTATATCAAA
CATGATAGGTGTGCATAAAGTGAATATTAATATCATTGATGGAGAAGTAGTTGTAGCATATGAAACACCCGCAAATTTAA
ATAGCATTGAAAAAGAAATTTATGATACAGGCTATAAAATTGTATATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT135150 WP_000138934.1 NZ_CP042286:c2263626-2263333 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT135150 NZ_CP042286:c2263626-2263333 [Staphylococcus argenteus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATTAAAACAAATCTTAAATCACGTTTAAATCGAATAGAAGGTCA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTTCTTACACAAATAAGAGCGACGCGTTCTG
CATTAAACAGTGTCGCAACAAAGTTATTAGAGCAACATATGAAAAGTTGTATTATGAATAAAGTAAATCAAGGTGCTCAA
GAAGAAGCGATGGAAGAGTTACTAGTTACTTTTCAAAAGTTGATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References