Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2242984..2243513 Replicon chromosome
Accession NZ_CP042286
Organism Staphylococcus argenteus strain B3-25B

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U7JQG1
Locus tag FPV14_RS10755 Protein ID WP_000621178.1
Coordinates 2242984..2243346 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag FPV14_RS10760 Protein ID WP_000948331.1
Coordinates 2243343..2243513 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPV14_RS10735 2239966..2240736 - 771 WP_001041104.1 RNA polymerase sigma factor SigB -
FPV14_RS10740 2240711..2241190 - 480 WP_047557424.1 anti-sigma B factor RsbW -
FPV14_RS10745 2241192..2241518 - 327 WP_001052491.1 anti-sigma factor antagonist -
FPV14_RS10750 2241635..2242636 - 1002 WP_000390825.1 PP2C family protein-serine/threonine phosphatase -
FPV14_RS10755 2242984..2243346 - 363 WP_000621178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FPV14_RS10760 2243343..2243513 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
FPV14_RS10765 2243598..2244746 - 1149 WP_001281137.1 alanine racemase -
FPV14_RS10770 2244816..2245175 - 360 WP_047557428.1 holo-ACP synthase -
FPV14_RS10775 2245179..2245682 - 504 WP_072467226.1 PH domain-containing protein -
FPV14_RS10780 2245669..2247252 - 1584 WP_146501804.1 PH domain-containing protein -
FPV14_RS10785 2247245..2247724 - 480 WP_047528519.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.79 Da        Isoelectric Point: 10.2892

>T135149 WP_000621178.1 NZ_CP042286:c2243346-2242984 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

>T135149 NZ_CP042286:c2243346-2242984 [Staphylococcus argenteus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTTGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCCA
AAATACCGACCCATGTAGAGATTGAAAAGAAAAAATATAAACTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGG
ACACTTGATAAAAAACGTTTAAAAGAAAAACTGACGTACTTATCAGACAACAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAACACAATGGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT135149 WP_000948331.1 NZ_CP042286:c2243513-2243343 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT135149 NZ_CP042286:c2243513-2243343 [Staphylococcus argenteus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCAATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References