Detailed information of TA system TA135148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2092287..2093065
• Replicon: chromosome
• Accession: NZ_CP042286
• Organism: Staphylococcus argenteus strain B3-25B

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: FPV14_RS09915
• Protein ID: WP_047557746.1
• Coordinates: 2092287..2092442 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A7U7JVF2
• Locus tag: FPV14_RS09920
• Protein ID: WP_047430475.1
• Coordinates: 2092466..2093065 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPV14_RS09895	2087476..2088588	-	1113	WP_031787927.1	GAF domain-containing sensor histidine kinase	-
FPV14_RS09900	2088750..2089571	+	822	WP_047557735.1	RluA family pseudouridine synthase	-
FPV14_RS09905	2089865..2091250	-	1386	WP_047557738.1	class II fumarate hydratase	-
FPV14_RS09910	2091421..2091822	-	402	WP_047557742.1	hypothetical protein	-
FPV14_RS09915	2092287..2092442	-	156	WP_047557746.1	hypothetical protein	Toxin
FPV14_RS09920	2092466..2093065	-	600	WP_047430475.1	glucosamine-6-phosphate isomerase	Antitoxin
FPV14_RS09925	2093224..2093694	-	471	WP_047557750.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
FPV14_RS09930	2093696..2094826	-	1131	WP_047557752.1	tRNA epoxyqueuosine(34) reductase QueG	-
FPV14_RS09935	2094977..2095699	-	723	WP_000590808.1	amino acid ABC transporter ATP-binding protein	-
FPV14_RS09940	2095692..2097149	-	1458	WP_000649887.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5989.39 Da
• Isoelectric Point: 4.1469

>T135148 WP_047557746.1 NZ_CP042286:c2092442-2092287 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSADEKNSH

Nucleotide

• Length: 156 bp

>T135148 NZ_CP042286:c2092442-2092287 [Staphylococcus argenteus]
ATGTCTAAAGATAAAGATGCAAAATTAAATTATCACGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAGATGGAACAAATTTCAGATCAAAATGATCAAGAGAAGAGTGCTGATGAAAAGAATAGCCATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22438.57 Da
• Isoelectric Point: 5.3935

>AT135148 WP_047430475.1 NZ_CP042286:c2093065-2092466 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT135148 NZ_CP042286:c2093065-2092466 [Staphylococcus argenteus]
ATGGCAATGAACTTTAAAGTATTTGACAACAGTCAACTTGTAGCAGAATATGCTGCAGATATTATTAGAAAACAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTGGATACAGACCAAGCACCAGTATTAGATGAACTAAAGAAAAACGTTG
AGAAACACGCTGTTGATTTTAGTCAAATAAATATTTTAGATTATGACAATAAAAAATCTTATTTTGAAGCATTAGGCGTG
CCAGCAAGTCAAATCTATCCAATTGCGTTTGAAAAAGATGCTATTGAATTTATCTCTGACAAAATTAAAACTAAAGAAAA
TAAAGGCAAACTAACATTACAAGTTGTTTCTATTGATGAGCAAGGAAAATTAAATGTTAGTATCCGCCAAGGTTTAATGG
AAGCGAGAGAAATATTTTTAGTTGTGACAGGTGCTAATAAAAAGGAAGTTGTTGAAAAATTATACCAAGAAAATGGTAAA
ACAAGTTTCGAACCATCTGACTTAAAATCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTCAAAGCTTACTTTACATCTCGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U7JVF2