Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1317386..1317999 Replicon chromosome
Accession NZ_CP042285
Organism Parabacteroides distasonis strain APCS2/PD

Toxin (Protein)


Gene name hicA Uniprot ID E1YXK9
Locus tag FQN59_RS05635 Protein ID WP_005866745.1
Coordinates 1317386..1317646 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID E1YXL0
Locus tag FQN59_RS05640 Protein ID WP_005866743.1
Coordinates 1317658..1317999 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQN59_RS05620 (FQN59_05760) 1313077..1314483 - 1407 WP_005866749.1 di-heme oxidoredictase family protein -
FQN59_RS05625 (FQN59_05765) 1314501..1315712 - 1212 WP_036652038.1 imelysin family protein -
FQN59_RS05630 (FQN59_05770) 1315743..1317056 - 1314 WP_005861166.1 porin -
FQN59_RS05635 (FQN59_05775) 1317386..1317646 + 261 WP_005866745.1 type II toxin-antitoxin system HicA family toxin Toxin
FQN59_RS05640 (FQN59_05780) 1317658..1317999 + 342 WP_005866743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FQN59_RS05645 (FQN59_05785) 1318331..1319236 - 906 WP_008773899.1 transcriptional regulator -
FQN59_RS05650 (FQN59_05790) 1319252..1319521 - 270 WP_005861164.1 hypothetical protein -
FQN59_RS22475 1320140..1320277 - 138 WP_249222511.1 hypothetical protein -
FQN59_RS05660 (FQN59_05805) 1320500..1320655 - 156 Protein_1112 AAA family ATPase -
FQN59_RS05665 (FQN59_05815) 1321032..1322579 + 1548 WP_170105881.1 arylsulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10036.60 Da        Isoelectric Point: 10.0271

>T135144 WP_005866745.1 NZ_CP042285:1317386-1317646 [Parabacteroides distasonis]
MGSKEKLIERFCKLPKDFTYEETLKLLSSYGYNEHNKGATSGSRVRFKNEQTGQYIDIHKPHPGSIMKEWMMKAIYQHLK
SNGLIK

Download         Length: 261 bp

>T135144 NZ_CP042285:1317386-1317646 [Parabacteroides distasonis]
ATGGGTTCTAAAGAAAAGTTGATCGAGCGTTTTTGTAAACTACCTAAAGATTTCACCTACGAGGAAACTTTAAAATTGCT
TTCTTCTTATGGCTATAACGAGCATAATAAAGGTGCAACGTCAGGTTCTCGCGTGAGATTTAAAAATGAACAGACGGGAC
AATATATTGATATTCATAAACCGCATCCGGGTAGTATTATGAAGGAGTGGATGATGAAAGCGATATATCAGCATTTAAAA
AGTAATGGTTTAATTAAATGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12391.06 Da        Isoelectric Point: 4.8780

>AT135144 WP_005866743.1 NZ_CP042285:1317658-1317999 [Parabacteroides distasonis]
MDYLEYKGYKGSVEYSKADNCLCGKVLGMSKDLILYEGNTIDELRADFEAGVESYLAGCLADGVEPRKPYSGTLNIRISP
EIHSRIAALAQEAGTTINGYIKQALENQLKLAH

Download         Length: 342 bp

>AT135144 NZ_CP042285:1317658-1317999 [Parabacteroides distasonis]
ATGGACTATTTGGAATACAAAGGTTATAAAGGTTCTGTTGAGTACAGTAAGGCTGATAACTGTCTTTGCGGAAAGGTACT
TGGTATGAGTAAAGATTTAATTCTTTATGAAGGTAATACTATCGATGAACTTCGTGCGGATTTTGAAGCCGGAGTAGAAA
GCTATCTTGCCGGCTGTTTGGCTGATGGCGTGGAACCTCGTAAACCTTATAGCGGCACGTTAAATATCCGTATTTCACCA
GAAATACATAGCCGAATCGCAGCATTGGCGCAAGAGGCGGGAACTACGATTAACGGGTATATAAAACAGGCTTTGGAGAA
TCAGTTGAAGCTTGCCCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A496DRY4

Antitoxin

Source ID Structure
AlphaFold DB A0A069SEG1

References