Detailed information of TA system TA135120

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5141780..5142305
• Replicon: chromosome
• Accession: NZ_CP042266
• Organism: Streptomyces qinzhouensis strain SSL-25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FQU76_RS22575
• Protein ID: WP_146482150.1
• Coordinates: 5141780..5142043 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FQU76_RS22580
• Protein ID: WP_146482151.1
• Coordinates: 5142036..5142305 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQU76_RS22555	5137764..5138777	+	1014	WP_186768138.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
FQU76_RS22560	5138808..5139563	+	756	WP_146482148.1	ROK family protein	-
FQU76_RS22565	5139591..5140190	-	600	WP_186768139.1	hypothetical protein	-
FQU76_RS22570	5140558..5141646	+	1089	WP_146482149.1	redox-regulated ATPase YchF	-
FQU76_RS22575	5141780..5142043	-	264	WP_146482150.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FQU76_RS22580	5142036..5142305	-	270	WP_146482151.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FQU76_RS22585	5142486..5143067	-	582	WP_146482152.1	Uma2 family endonuclease	-
FQU76_RS22590	5143093..5143455	-	363	WP_146482153.1	DUF4326 domain-containing protein	-
FQU76_RS22595	5143723..5145162	+	1440	WP_146482154.1	DUF4190 domain-containing protein	-
FQU76_RS22600	5145478..5146821	-	1344	WP_146482155.1	glycoside hydrolase family 18 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 10.2291

>T135120 WP_146482150.1 NZ_CP042266:c5142043-5141780 [Streptomyces qinzhouensis]
VSEYRTVFRPEAQAELRKIPRDIALRILARPTELETAPLDFNTTALVSQLERRRLRVGDYRVVYTINNGELVARVVHVGH
RSTVHET

Nucleotide

• Length: 264 bp

>T135120 NZ_CP042266:c5142043-5141780 [Streptomyces qinzhouensis]
GTGAGTGAGTACCGAACCGTCTTCCGCCCCGAGGCGCAGGCCGAACTCCGGAAGATCCCGCGCGACATAGCACTGCGTAT
CCTGGCCAGGCCGACCGAGCTGGAGACCGCCCCTCTCGACTTCAACACCACCGCGCTCGTGTCTCAGCTCGAACGTCGCC
GCCTGCGCGTGGGCGACTACCGCGTCGTCTACACGATCAACAACGGGGAACTGGTGGCCCGGGTCGTTCACGTGGGACAC
CGGTCCACCGTCCACGAGACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10157.62 Da
• Isoelectric Point: 5.9008

>AT135120 WP_146482151.1 NZ_CP042266:c5142305-5142036 [Streptomyces qinzhouensis]
MTQPLPIESIRNGRAHLAEVVERADRDDVPTVITRRGKQIAATVSIEVLRKYQEWEEREINRIIDKRMAGPAPGIPIEDI
MRETPARGE

Nucleotide

• Length: 270 bp

>AT135120 NZ_CP042266:c5142305-5142036 [Streptomyces qinzhouensis]
ATGACGCAGCCGCTGCCCATAGAGTCCATCCGCAATGGGCGCGCACACCTCGCCGAAGTCGTGGAGCGGGCCGACCGGGA
CGATGTACCCACCGTGATCACCCGGCGCGGCAAGCAGATCGCCGCCACGGTGTCGATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAACGCGAGATCAACCGGATCATCGACAAGCGCATGGCCGGTCCGGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACACCGGCTCGCGGTGAGTGA