Detailed information of TA system TA135119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3395692..3396320
• Replicon: chromosome
• Accession: NZ_CP042266
• Organism: Streptomyces qinzhouensis strain SSL-25

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FQU76_RS14330
• Protein ID: WP_146480846.1
• Coordinates: 3395692..3396102 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FQU76_RS14335
• Protein ID: WP_186768031.1
• Coordinates: 3396099..3396320 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQU76_RS14310	3392171..3392689	+	519	WP_186768343.1	flavin reductase family protein	-
FQU76_RS14315	3392835..3393263	-	429	WP_146480843.1	aminoacyl-tRNA hydrolase	-
FQU76_RS14320	3393519..3394094	+	576	WP_146480844.1	TerD family protein	-
FQU76_RS14325	3394225..3395640	-	1416	WP_146480845.1	M1 family metallopeptidase	-
FQU76_RS14330	3395692..3396102	-	411	WP_146480846.1	PIN domain-containing protein	Toxin
FQU76_RS14335	3396099..3396320	-	222	WP_186768031.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FQU76_RS14340	3396450..3397007	-	558	WP_146480848.1	heme-binding protein	-
FQU76_RS14345	3397276..3398571	+	1296	WP_146480849.1	sensor histidine kinase	-
FQU76_RS14350	3398568..3399215	+	648	WP_186768032.1	response regulator transcription factor	-
FQU76_RS14355	3399267..3399740	-	474	WP_146480850.1	carboxymuconolactone decarboxylase family protein	-
FQU76_RS14360	3399891..3400331	+	441	WP_186768033.1	RidA family protein	-
FQU76_RS14365	3400490..3401098	+	609	WP_146480851.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (4-43)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15115.74 Da
• Isoelectric Point: 6.1508

>T135119 WP_146480846.1 NZ_CP042266:c3396102-3395692 [Streptomyces qinzhouensis]
VIYLLDTSGLVRFLRDSKLQDAWRDAVDAGTVGSCYPQRAEFLHSARSAREFDEITEFFADFLPDVAVPKNAGRWIDGVQ
HRLARAGEHRSASAVDLIIAATAAHHGLVVLHDDADYRAVARHASDFTEHNIHDHS

Nucleotide

• Length: 411 bp

>T135119 NZ_CP042266:c3396102-3395692 [Streptomyces qinzhouensis]
GTGATCTACCTGCTCGACACCTCCGGTCTCGTCCGGTTCCTTCGCGACTCGAAACTTCAGGACGCCTGGCGTGATGCCGT
CGACGCAGGCACCGTCGGGTCCTGCTATCCGCAGCGGGCCGAGTTTCTCCACAGTGCCAGGAGTGCCCGCGAGTTCGACG
AGATCACGGAGTTCTTCGCGGATTTCCTTCCCGATGTCGCCGTGCCGAAGAACGCGGGACGCTGGATCGACGGGGTGCAG
CACCGGCTTGCTCGCGCAGGCGAGCACCGCAGTGCCTCCGCGGTCGACCTGATCATCGCGGCTACAGCCGCTCACCATGG
ACTCGTCGTCCTCCACGACGACGCCGACTACCGTGCCGTCGCCCGCCACGCATCTGATTTCACCGAGCACAATATTCACG
ACCACAGCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8361.47 Da
• Isoelectric Point: 8.7020

>AT135119 WP_186768031.1 NZ_CP042266:c3396320-3396099 [Streptomyces qinzhouensis]
MAVTQIDIDDEALARTMALARVRTKKEAVNLALAFYADRQERAARLSRHLERAKGWGAVEDAERLHEAEKRDR

Nucleotide

• Length: 222 bp

>AT135119 NZ_CP042266:c3396320-3396099 [Streptomyces qinzhouensis]
ATGGCAGTGACCCAGATCGACATCGACGATGAGGCCTTGGCGCGGACCATGGCCCTGGCGAGGGTCAGAACCAAAAAGGA
AGCGGTCAATCTGGCCCTTGCCTTTTACGCCGACCGGCAGGAGCGCGCAGCCCGCCTCAGCCGCCATCTCGAGCGGGCGA
AGGGATGGGGAGCGGTCGAGGACGCCGAGCGGCTTCACGAGGCGGAGAAGCGCGACCGGTGA