Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2154342..2154978 Replicon chromosome
Accession NZ_CP042252
Organism Bacillus licheniformis strain KNU11

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag FQB22_RS10925 Protein ID WP_003179128.1
Coordinates 2154628..2154978 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag FQB22_RS10920 Protein ID WP_006638778.1
Coordinates 2154342..2154623 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQB22_RS10900 2149457..2150938 + 1482 WP_009330132.1 PH domain-containing protein -
FQB22_RS10905 2150935..2151534 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
FQB22_RS10910 2151877..2152836 + 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
FQB22_RS10915 2153061..2154230 + 1170 WP_025807384.1 alanine racemase -
FQB22_RS10920 2154342..2154623 + 282 WP_006638778.1 hypothetical protein Antitoxin
FQB22_RS10925 2154628..2154978 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FQB22_RS10930 2155096..2155923 + 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
FQB22_RS10935 2155927..2156292 + 366 WP_003179132.1 STAS domain-containing protein -
FQB22_RS10940 2156295..2156696 + 402 WP_003179135.1 anti-sigma regulatory factor -
FQB22_RS10945 2156707..2157714 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
FQB22_RS10950 2157773..2158099 + 327 WP_003179140.1 anti-sigma factor antagonist -
FQB22_RS10955 2158099..2158584 + 486 WP_003179142.1 anti-sigma B factor RsbW -
FQB22_RS10960 2158550..2159341 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
FQB22_RS10965 2159338..2159937 + 600 WP_003179145.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T135112 WP_003179128.1 NZ_CP042252:2154628-2154978 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T135112 NZ_CP042252:2154628-2154978 [Bacillus licheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGACTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT135112 WP_006638778.1 NZ_CP042252:2154342-2154623 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT135112 NZ_CP042252:2154342-2154623 [Bacillus licheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTACGCGAACGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATCAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References