Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 1068990..1069806 Replicon chromosome
Accession NZ_CP042251
Organism Geobacillus thermoleovorans strain ARTRW1

Toxin (Protein)


Gene name hepT Uniprot ID G8MYR9
Locus tag FP515_RS05650 Protein ID WP_014195290.1
Coordinates 1068990..1069409 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID G8MYS0
Locus tag FP515_RS05655 Protein ID WP_014195291.1
Coordinates 1069399..1069806 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP515_RS05625 1065765..1066280 + 516 WP_014195285.1 GNAT family N-acetyltransferase -
FP515_RS05630 1066352..1067623 + 1272 WP_122983902.1 DUF3533 domain-containing protein -
FP515_RS05635 1067648..1067860 + 213 WP_014195287.1 ATP-binding cassette domain-containing protein -
FP515_RS05640 1067827..1068297 + 471 Protein_1019 ABC transporter permease -
FP515_RS05645 1068309..1068962 + 654 WP_014195289.1 TetR/AcrR family transcriptional regulator -
FP515_RS05650 1068990..1069409 - 420 WP_014195290.1 DUF86 domain-containing protein Toxin
FP515_RS05655 1069399..1069806 - 408 WP_014195291.1 nucleotidyltransferase domain-containing protein Antitoxin
FP515_RS05660 1070087..1072219 - 2133 WP_014195292.1 ATP-dependent Clp protease ATP-binding subunit -
FP515_RS05665 1072487..1073233 + 747 WP_025039183.1 FixH family protein -
FP515_RS05670 1073341..1074381 + 1041 WP_014195294.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(9-98)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15907.43 Da        Isoelectric Point: 8.2859

>T135110 WP_014195290.1 NZ_CP042251:c1069409-1068990 [Geobacillus thermoleovorans]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS

Download         Length: 420 bp

>T135110 NZ_CP042251:c1069409-1068990 [Geobacillus thermoleovorans]
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAGGCATGCATCGATT
TGGCCATGCATATTGTGGCCGAGCAGAAATTCGGATTGCCGCAGCATAGCCGCGATGCATTCGCTCTCCTCGAAGAACAT
GGGGTCATCTCCCCTTCCATAAGCAAAAAGATGAAGGCGATGGTCGGATTCCGCAACATCGCCGTTCACGACTATCAACA
ACTGAACCTTGGCATCTTGCAAGCCATCGTCGAACACCATCTTGATGATTTCAAACAATTTACGAAAGCCATCCTCGATT
ATGCTAAGAAAAACAGCTAG

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15273.46 Da        Isoelectric Point: 4.8382

>AT135110 WP_014195291.1 NZ_CP042251:c1069806-1069399 [Geobacillus thermoleovorans]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGRDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK

Download         Length: 408 bp

>AT135110 NZ_CP042251:c1069806-1069399 [Geobacillus thermoleovorans]
TTGCCAAACGAAATGGAGACGATCATCATTCAGACGCTCCGCCCGGCTCTTCACCCGTTCGTCATCTACCTGTTCGGTTC
AGCCGCCCGTGGGACGCTGCGCCCAGACAGCGATGTCGACATCGCCTTTGTCAGCGACGGCGAACCGCATGATCCGTATG
AGCTGTTTCGGCTCGCCGGGGAGTTGGCTGACAAGTTAGGGCGAGATGTCGATCTTGTCGATTTGCGCCAAGCCAGCACC
GTGTTTCAAGCGCAAGTCGTCTCGACGGGAAAAGCCATTGATTGCCGCGACGAGCGGAAACGGGCTGAGTTCGAAATGAA
AACATTGAAAATGTATGTGAAACTAAACGAAGAGAGAGCACCGGTGTTAAAACAAATTACGGAAAGCGGGAGCATATATG
AAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8MYR9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9EPL2

References