Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 242410..243046 Replicon chromosome
Accession NZ_CP042251
Organism Geobacillus thermoleovorans strain ARTRW1

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag FP515_RS01325 Protein ID WP_003253417.1
Coordinates 242696..243046 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag FP515_RS01320 Protein ID WP_011229742.1
Coordinates 242410..242691 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP515_RS01300 238667..239284 - 618 WP_014194682.1 rhomboid family intramembrane serine protease -
FP515_RS01305 239398..239787 + 390 WP_011229738.1 holo-ACP synthase -
FP515_RS01310 239867..240880 + 1014 WP_014194683.1 outer membrane lipoprotein carrier protein LolA -
FP515_RS01315 241129..242283 + 1155 WP_011229741.1 alanine racemase -
FP515_RS01320 242410..242691 + 282 WP_011229742.1 hypothetical protein Antitoxin
FP515_RS01325 242696..243046 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FP515_RS01330 243378..245543 + 2166 WP_014194685.1 RNA-binding transcriptional accessory protein -
FP515_RS01335 245562..245675 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
FP515_RS01340 245765..246214 + 450 WP_013144047.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T135109 WP_003253417.1 NZ_CP042251:242696-243046 [Geobacillus thermoleovorans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T135109 NZ_CP042251:242696-243046 [Geobacillus thermoleovorans]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGACCTTTCCCCGGTTGTTGGCTCGGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGTTTTAGCCCGACGGTGATTGTCGCGGCGATTACGGCGCAAATCCAAAAAG
CGAAGCTGCCGACGCATGTCGAGATTGACGCGAAACGCTACGGGTTTGAACGCGATTCGGTCATTTTGCTTGAGCAAATT
CGCACGATCGACAAGCAACGGCTGACCGATAAAATCACTCATTTGGACGATGAAATGATGGATAAAGTCGATGAGGCGCT
GCAAATTAGCTTAGGGCTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT135109 WP_011229742.1 NZ_CP042251:242410-242691 [Geobacillus thermoleovorans]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT135109 NZ_CP042251:242410-242691 [Geobacillus thermoleovorans]
GTGTCGGAATCTGGCGCAACAGCGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGTGCTCGTAAA
GCAGGAAAACGGCAACCGCAATGAACTCATTTATCAAGCGACGAAAATGTACATTCGCGAGCGGAAGAAACGGCAAATTC
GTGAGGCGATGAGACGAGGCTACATGGAAATGGCGAAAATCAATTTATCTATCGCTTCTGAAGCGTTTCATGCTGAATAC
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9ETW5

References