Detailed information of TA system TA135107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 4679737..4680725
• Replicon: chromosome
• Accession: NZ_CP042250
• Organism: Escherichia coli strain BCE049

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FQU84_RS25100
• Protein ID: WP_014640052.1
• Coordinates: 4679737..4680123 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0A1AFM1
• Locus tag: FQU84_RS25105
• Protein ID: WP_000458583.1
• Coordinates: 4680153..4680725 (-)
• Length: 191 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQU84_RS25055	4675001..4675825	+	825	WP_000081297.1	YfdQ family protein	-
FQU84_RS25060	4675953..4676489	+	537	WP_000008216.1	5'-deoxynucleotidase	-
FQU84_RS25065	4676480..4676830	+	351	WP_001242737.1	hypothetical protein	-
FQU84_RS25070	4676827..4677312	+	486	WP_000145690.1	class I SAM-dependent methyltransferase	-
FQU84_RS25075	4677309..4677827	+	519	WP_001318178.1	ead/Ea22-like family protein	-
FQU84_RS25080	4677829..4678017	+	189	WP_001014286.1	hypothetical protein	-
FQU84_RS25085	4678020..4678586	+	567	WP_000208054.1	DUF551 domain-containing protein	-
FQU84_RS25090	4678586..4679158	+	573	WP_001061340.1	3'-5' exoribonuclease	-
FQU84_RS25095	4679195..4679476	+	282	WP_001093916.1	pyocin activator PrtN family protein	-
FQU84_RS27275	4679524..4679697	-	174	WP_000390071.1	hypothetical protein	-
FQU84_RS25100	4679737..4680123	-	387	WP_014640052.1	hypothetical protein	Toxin
FQU84_RS25105	4680153..4680725	-	573	WP_000458583.1	SocA family protein	Antitoxin
FQU84_RS25110	4681196..4681711	+	516	WP_000416264.1	zinc uptake transcriptional repressor Zur	-
FQU84_RS25115	4681753..4681962	-	210	WP_001296638.1	CsbD family protein	-
FQU84_RS25120	4682078..4683403	-	1326	WP_001296637.1	MATE family efflux transporter DinF	-
FQU84_RS25125	4683476..4684084	-	609	WP_000646078.1	transcriptional repressor LexA	-
FQU84_RS25130	4684194..4684562	-	369	WP_000002899.1	diacylglycerol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4637082..4684084	47002

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-137)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14465.40 Da
• Isoelectric Point: 5.4833

>T135107 WP_014640052.1 NZ_CP042250:c4680123-4679737 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Nucleotide

• Length: 387 bp

>T135107 NZ_CP042250:c4680123-4679737 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGGGTCCCCCACGATCCGTCTTGCGTCTTGAATTCCGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 191 a.a.
• Molecular weight: 21956.30 Da
• Isoelectric Point: 6.0283

>AT135107 WP_000458583.1 NZ_CP042250:c4680725-4680153 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHDVLLRSDPREMDADEVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Nucleotide

• Length: 573 bp

>AT135107 NZ_CP042250:c4680725-4680153 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAATTTGATTCGTGGTAAGGCTGAAGGCATTGGTGACTACTGGTACAAC
TTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGCATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Antitoxin

• AlphaFold DB: A0A0A1AFM1