Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4317063..4317861 Replicon chromosome
Accession NZ_CP042250
Organism Escherichia coli strain BCE049

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X1M0U2
Locus tag FQU84_RS23220 Protein ID WP_000854919.1
Coordinates 4317063..4317440 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2G4AEZ5
Locus tag FQU84_RS23225 Protein ID WP_001285608.1
Coordinates 4317487..4317861 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU84_RS23190 4312563..4312742 + 180 WP_001298063.1 hypothetical protein -
FQU84_RS23195 4313141..4315177 - 2037 WP_000417001.1 hypothetical protein -
FQU84_RS27245 4316130..4316276 - 147 WP_001290177.1 hypothetical protein -
FQU84_RS23210 4316361..4316558 - 198 WP_001403937.1 DUF957 domain-containing protein -
FQU84_RS23215 4316578..4317066 - 489 WP_000777665.1 hypothetical protein -
FQU84_RS23220 4317063..4317440 - 378 WP_000854919.1 TA system toxin CbtA family protein Toxin
FQU84_RS23225 4317487..4317861 - 375 WP_001285608.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
FQU84_RS23230 4317941..4318162 - 222 WP_000692350.1 DUF987 domain-containing protein -
FQU84_RS23235 4318249..4318725 - 477 WP_001186188.1 RadC family protein -
FQU84_RS23240 4318740..4319219 - 480 WP_000706980.1 antirestriction protein -
FQU84_RS27250 4319319..4319459 + 141 WP_000997937.1 hypothetical protein -
FQU84_RS23245 4319485..4320303 - 819 WP_001175165.1 DUF945 domain-containing protein -
FQU84_RS23250 4320393..4320626 - 234 WP_001278293.1 DUF905 family protein -
FQU84_RS23255 4320632..4321309 - 678 WP_001097301.1 hypothetical protein -
FQU84_RS23260 4321457..4322137 - 681 WP_001282921.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4306479..4332082 25603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.97 Da        Isoelectric Point: 7.9086

>T135105 WP_000854919.1 NZ_CP042250:c4317440-4317063 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

>T135105 NZ_CP042250:c4317440-4317063 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13610.37 Da        Isoelectric Point: 5.5051

>AT135105 WP_001285608.1 NZ_CP042250:c4317861-4317487 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPAITS

Download         Length: 375 bp

>AT135105 NZ_CP042250:c4317861-4317487 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1M0U2

Antitoxin

Source ID Structure
AlphaFold DB A0A2G4AEZ5

References