Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 59277..59833 Replicon plasmid pBCE049-1
Accession NZ_CP042247
Organism Escherichia coli strain BCE049

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FQU84_RS00260 Protein ID WP_050939058.1
Coordinates 59277..59552 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FQU84_RS00265 Protein ID WP_050939060.1
Coordinates 59552..59833 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU84_RS00230 54559..55077 - 519 WP_050939047.1 alpha-hemolysin-activating lysine-acyltransferase HlyC -
FQU84_RS00240 56342..56584 - 243 Protein_41 transposase -
FQU84_RS00245 56643..57795 + 1153 Protein_42 IS3 family transposase -
FQU84_RS00250 58402..58653 + 252 WP_050939053.1 hypothetical protein -
FQU84_RS00255 58890..59171 - 282 WP_050939055.1 hypothetical protein -
FQU84_RS00260 59277..59552 - 276 WP_050939058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FQU84_RS00265 59552..59833 - 282 WP_050939060.1 ribbon-helix-helix protein, CopG family Antitoxin
FQU84_RS00270 60426..60884 - 459 WP_061336502.1 hypothetical protein -
FQU84_RS27025 60881..61676 - 796 Protein_48 3'-5' exonuclease -
FQU84_RS00285 61722..61999 - 278 Protein_49 type II toxin-antitoxin system RelE/ParE family toxin -
FQU84_RS00290 61996..62154 - 159 WP_077793267.1 toxin-antitoxin system protein -
FQU84_RS00295 62189..62854 + 666 WP_072095473.1 transposase -
FQU84_RS00300 63105..64109 - 1005 WP_050939068.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - cdtC / cdtB / cdtA / cnf1 / hlyD / hlyB / hlyA / hlyC / iutA / iucD / iucC / iucB / iucA 1..142705 142705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10753.44 Da        Isoelectric Point: 9.9324

>T135067 WP_050939058.1 NZ_CP042247:c59552-59277 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFETREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T135067 NZ_CP042247:c59552-59277 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAAACCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10335.74 Da        Isoelectric Point: 6.4601

>AT135067 WP_050939060.1 NZ_CP042247:c59833-59552 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEERNRLTLEALDDVTSGQVIDHQAVQAWA
DSLSTDNPLSVPR

Download         Length: 282 bp

>AT135067 NZ_CP042247:c59833-59552 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGC
GTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGGCAGGTTATCGACCATCAGGCTGTACAGGCCTGGGCG
GACAGCCTCAGTACTGACAATCCGTTATCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References