Detailed information of TA system TA135021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1311652..1312233
• Replicon: chromosome
• Accession: NZ_CP042242
• Organism: Oxalobacter formigenes strain SSYG-15

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FPZ51_RS06005
• Protein ID: WP_086131780.1
• Coordinates: 1311940..1312233 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FPZ51_RS06000
• Protein ID: WP_086131781.1
• Coordinates: 1311652..1311936 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ51_RS05960	1307568..1307927	-	360	WP_086131789.1	DUF4406 domain-containing protein	-
FPZ51_RS05965	1307917..1308333	-	417	WP_086131827.1	DUF3310 domain-containing protein	-
FPZ51_RS05970	1308703..1308882	-	180	WP_086131788.1	hypothetical protein	-
FPZ51_RS11390	1308886..1309026	-	141	WP_157661015.1	hypothetical protein	-
FPZ51_RS05975	1309035..1309565	-	531	WP_145814966.1	hypothetical protein	-
FPZ51_RS05980	1309774..1310244	-	471	WP_086131786.1	helix-turn-helix domain-containing protein	-
FPZ51_RS05985	1310218..1310442	+	225	WP_186447524.1	hypothetical protein	-
FPZ51_RS05990	1310468..1310926	+	459	WP_086131784.1	hypothetical protein	-
FPZ51_RS11395	1311093..1311233	+	141	WP_157661014.1	hypothetical protein	-
FPZ51_RS05995	1311230..1311625	+	396	WP_086131782.1	winged helix-turn-helix domain-containing protein	-
FPZ51_RS06000	1311652..1311936	-	285	WP_086131781.1	putative addiction module antidote protein	Antitoxin
FPZ51_RS06005	1311940..1312233	-	294	WP_086131780.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FPZ51_RS06010	1312325..1313047	+	723	WP_086131779.1	hypothetical protein	-
FPZ51_RS06015	1313040..1313885	+	846	WP_086131778.1	KilA-N domain-containing protein	-
FPZ51_RS06020	1313878..1316391	+	2514	WP_086131777.1	hypothetical protein	-
FPZ51_RS06025	1316714..1317073	+	360	WP_086131775.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1302356..1340435	38079

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Uncharacterized protein HI1420 (2-90)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10925.66 Da
• Isoelectric Point: 10.8032

>T135021 WP_086131780.1 NZ_CP042242:c1312233-1311940 [Oxalobacter formigenes]
MKYTIKQTETFKTWLKTVKDRTAFIAIIRRLERAGNGNFGDAKSINDGVSEMRVDVGAGYRLYYTIRGNEIVFFLNGGKK
STQKSDIKIAKSKAKGI

Nucleotide

• Length: 294 bp

>T135021 NZ_CP042242:c1312233-1311940 [Oxalobacter formigenes]
ATGAAATACACAATCAAACAAACCGAAACATTTAAAACGTGGCTCAAAACAGTCAAGGATAGAACGGCATTTATTGCCAT
CATCAGAAGACTTGAAAGAGCCGGAAACGGCAATTTCGGGGATGCCAAGTCGATTAATGACGGTGTTTCTGAAATGCGCG
TCGATGTCGGTGCAGGTTATCGCTTGTATTACACCATTCGCGGAAATGAGATCGTGTTTTTCCTGAACGGTGGAAAAAAG
TCCACACAGAAATCGGATATTAAAATCGCAAAAAGCAAGGCGAAAGGAATTTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10617.06 Da
• Isoelectric Point: 5.1514

>AT135021 WP_086131781.1 NZ_CP042242:c1311936-1311652 [Oxalobacter formigenes]
MTEKTHTFDIVEYLDSEENVQEYFRQVMEDGDSDEIIRALGHIAKARGMMKLANDTGLARESLYRALSEGAKPRFDTIMR
VTQALGLKLTIAHG

Nucleotide

• Length: 285 bp

>AT135021 NZ_CP042242:c1311936-1311652 [Oxalobacter formigenes]
ATGACTGAAAAAACACACACTTTTGACATAGTTGAATATCTGGACAGTGAAGAAAACGTCCAGGAATATTTCAGACAAGT
CATGGAAGACGGCGACTCCGATGAAATTATCCGGGCGCTCGGCCACATCGCCAAAGCGCGGGGCATGATGAAACTTGCAA
ATGATACCGGACTCGCCAGAGAAAGCCTTTACAGGGCGCTTTCTGAAGGCGCAAAACCGCGTTTTGACACGATTATGCGC
GTCACTCAAGCCCTTGGCCTGAAACTGACTATTGCGCACGGCTGA