Detailed information of TA system TA135019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 890009..891486
• Replicon: chromosome
• Accession: NZ_CP042242
• Organism: Oxalobacter formigenes strain SSYG-15

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: C3X8C7
• Locus tag: FPZ51_RS04085
• Protein ID: WP_005879940.1
• Coordinates: 890230..891486 (+)
• Length: 419 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: FPZ51_RS04080
• Protein ID: WP_005879938.1
• Coordinates: 890009..890233 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ51_RS04065	888066..888521	-	456	WP_036602661.1	pyridoxamine 5'-phosphate oxidase family protein	-
FPZ51_RS04070	888533..889180	-	648	WP_036603576.1	NAD(P)H-binding protein	-
FPZ51_RS04075	889443..889820	+	378	WP_036602664.1	DUF1622 domain-containing protein	-
FPZ51_RS04080	890009..890233	+	225	WP_005879938.1	helix-turn-helix transcriptional regulator	Antitoxin
FPZ51_RS04085	890230..891486	+	1257	WP_005879940.1	type II toxin-antitoxin system HipA family toxin	Toxin
FPZ51_RS04090	891495..892370	-	876	WP_005879942.1	hypothetical protein	-
FPZ51_RS04095	892427..893293	-	867	WP_005879944.1	hypothetical protein	-
FPZ51_RS04100	894239..894721	+	483	WP_186447499.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (146-351)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-66)

Sequences

Toxin

Protein

• Length: 419 a.a.
• Molecular weight: 46365.63 Da
• Isoelectric Point: 6.7525

>T135019 WP_005879940.1 NZ_CP042242:890230-891486 [Oxalobacter formigenes]
MSRILDVYLHEKMAGTLAQNENGQLVFKYNSNYLDSNGMAISVSMPLRDEPYPDRIARPYFAGLLPDERARRRLAAVLGV
SDENVFGLLEIIGGECAGALSLLPQGQPLPDFSTGTVEVLDGKRLAELLDLLRQKPLLGGVEGIRLSLAGAQDKLAVCFI
DGQIFLPKNGLPTTHILKPFIEGLSGTVENEVFCMMLAGRVGLDAPVVSKGMAGNTGFILVERYDRVREENGRILRLHQE
DFCQALGVPPEIKYESEGGPGIASSQALIQNVTQRPAADRRAFQQRVIFHYLVGNADAHAKNYSLLYQGKTPVLAPVYDV
VCTDVYSLAKNMAMKIGERSLPDTIRLEDWQKMVPDTRVAKRILSDDLLRMANGIEIEADRLLEELNDQNLYHPVLKKIR
RTIGVRVRTIQKLMEKIA

Nucleotide

• Length: 1257 bp

>T135019 NZ_CP042242:890230-891486 [Oxalobacter formigenes]
ATGAGTCGCATTCTTGATGTTTACCTTCATGAAAAGATGGCGGGTACGCTGGCGCAAAATGAGAATGGCCAACTTGTTTT
CAAATATAACAGTAATTATCTGGATTCAAACGGGATGGCAATTTCAGTATCGATGCCTTTACGTGATGAGCCTTACCCGG
ACAGGATCGCTCGTCCGTACTTTGCCGGTTTGTTGCCGGACGAACGTGCGCGACGTCGTCTTGCGGCTGTGTTGGGTGTT
TCTGATGAAAATGTTTTCGGTTTGCTGGAGATAATCGGTGGTGAATGTGCAGGTGCACTTTCCCTGTTACCGCAAGGACA
ACCGTTGCCCGATTTTTCTACCGGAACTGTCGAGGTACTCGACGGGAAACGTCTTGCTGAACTGCTGGACCTGTTACGGC
AAAAACCATTGCTTGGAGGTGTGGAAGGAATTCGCTTATCTCTTGCCGGGGCACAGGATAAACTGGCCGTTTGTTTCATT
GACGGGCAAATTTTTTTGCCCAAAAACGGACTTCCGACCACACATATTCTCAAACCTTTTATCGAAGGATTGAGCGGAAC
GGTTGAAAACGAGGTTTTCTGTATGATGCTGGCGGGGCGCGTGGGATTGGATGCGCCTGTCGTTTCCAAAGGCATGGCAG
GAAATACCGGATTCATTCTTGTTGAACGTTATGACCGTGTGCGCGAAGAGAATGGCAGGATTTTACGCTTGCATCAGGAA
GATTTCTGTCAGGCTCTGGGTGTGCCGCCGGAAATTAAATATGAATCGGAAGGTGGGCCGGGAATAGCCAGTTCACAGGC
GTTGATCCAGAATGTAACGCAGAGGCCGGCTGCCGATCGTCGTGCTTTTCAGCAAAGGGTGATTTTTCATTATCTGGTGG
GAAACGCGGATGCTCATGCCAAAAATTATTCCCTGCTATATCAGGGCAAGACGCCCGTTCTGGCTCCGGTTTACGATGTC
GTATGTACAGATGTATATTCTCTTGCAAAGAATATGGCCATGAAAATTGGTGAGCGCTCTCTGCCAGATACCATACGATT
GGAAGACTGGCAAAAAATGGTACCGGACACCCGGGTGGCAAAAAGGATATTGTCTGATGATTTATTACGAATGGCGAATG
GTATAGAAATCGAAGCGGACAGGCTTCTGGAAGAATTGAACGACCAAAATCTTTATCATCCGGTGTTGAAAAAAATCAGG
AGAACGATCGGTGTCCGGGTGCGAACGATTCAAAAGCTTATGGAAAAAATTGCCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8124.44 Da
• Isoelectric Point: 10.5957

>AT135019 WP_005879938.1 NZ_CP042242:890009-890233 [Oxalobacter formigenes]
MTSVQNHIALGNLVRIERKRQKLTQEQLAALAGVGVRFLRELEKGKDSCRIGLAFSVMQTLGLSVDVSGRGDEK

Nucleotide

• Length: 225 bp

>AT135019 NZ_CP042242:890009-890233 [Oxalobacter formigenes]
ATGACTTCAGTTCAAAATCATATTGCACTTGGCAATCTTGTTCGTATCGAACGGAAGCGTCAGAAGTTGACACAGGAGCA
ACTGGCTGCGCTTGCCGGTGTGGGTGTCCGGTTTTTACGTGAGCTGGAAAAAGGAAAGGACAGTTGTCGAATCGGTCTTG
CGTTTTCTGTCATGCAAACCCTTGGGTTGTCTGTGGATGTTTCCGGAAGAGGAGACGAAAAATGA

Structures

Toxin

• AlphaFold DB: C3X8C7