Detailed information of TA system TA135017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/CC2985(antitoxin)
• Location: 953907..954451
• Replicon: chromosome
• Accession: NZ_CP042239
• Organism: Sphingomonas sp. XS-10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FPZ54_RS04565
• Protein ID: WP_145845346.1
• Coordinates: 954170..954451 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FPZ54_RS04560
• Protein ID: WP_145845344.1
• Coordinates: 953907..954173 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ54_RS04540	950763..951416	-	654	WP_145849572.1	2OG-Fe(II) oxygenase	-
FPZ54_RS04545	951524..952642	+	1119	WP_145845341.1	hypothetical protein	-
FPZ54_RS04555	952813..953865	+	1053	WP_145845342.1	NAD(P)-binding domain-containing protein	-
FPZ54_RS04560	953907..954173	+	267	WP_145845344.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FPZ54_RS04565	954170..954451	+	282	WP_145845346.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FPZ54_RS04575	955265..956293	+	1029	WP_145845348.1	lytic murein transglycosylase	-
FPZ54_RS04580	956277..957110	+	834	WP_186456914.1	SPOR domain-containing protein	-
FPZ54_RS04585	957137..958303	+	1167	WP_145845350.1	D-alanyl-D-alanine carboxypeptidase	-
FPZ54_RS04590	958300..958923	+	624	WP_145845352.1	dTMP kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10640.30 Da
• Isoelectric Point: 8.0816

>T135017 WP_145845346.1 NZ_CP042239:954170-954451 [Sphingomonas sp. XS-10]
MRLVFAPAAQADLREIAAYIAEDDPDHARSFVAELRKACVILIDHPFLGMARPEVGDGLRSKPHGRYAIFYRVIEDVVRI
ERVIHTSRDKQRL

Nucleotide

• Length: 282 bp

>T135017 NZ_CP042239:954170-954451 [Sphingomonas sp. XS-10]
ATGAGGCTGGTTTTCGCGCCTGCGGCCCAGGCCGACCTGCGCGAAATTGCAGCCTATATCGCTGAGGACGATCCAGATCA
CGCGAGATCCTTCGTCGCAGAGCTAAGAAAGGCGTGCGTGATCCTGATTGACCACCCGTTTCTCGGAATGGCCCGGCCCG
AGGTCGGCGATGGATTGCGCTCGAAGCCGCACGGCCGATATGCGATCTTTTATCGCGTGATTGAAGACGTGGTGCGTATC
GAGCGCGTTATCCACACCTCTCGGGATAAACAGCGACTATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9561.68 Da
• Isoelectric Point: 4.4508

>AT135017 WP_145845344.1 NZ_CP042239:953907-954173 [Sphingomonas sp. XS-10]
MPSSFTLGSHFEGFIKRQVSSGRYASASEVIRDSLRLLEEQEEERAAKLEALRADIAYGAASGEGIPADEVFAEVEAMID
EIARKKAG

Nucleotide

• Length: 267 bp

>AT135017 NZ_CP042239:953907-954173 [Sphingomonas sp. XS-10]
ATGCCCTCCAGCTTCACCCTCGGCAGCCATTTCGAAGGTTTCATCAAGCGTCAGGTCAGTTCTGGCCGCTATGCGTCCGC
CAGCGAAGTGATCCGCGACAGCCTGCGCCTGCTCGAGGAGCAGGAGGAGGAGCGCGCCGCGAAGCTTGAGGCGTTGCGCG
CCGATATCGCCTATGGCGCGGCAAGCGGCGAAGGCATCCCCGCCGATGAGGTCTTCGCCGAGGTGGAGGCCATGATCGAC
GAGATCGCCCGCAAGAAAGCCGGATGA