Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3917733..3918475 Replicon chromosome
Accession NZ_CP042220
Organism Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)


Gene name ataT Uniprot ID A0A5B8IDH8
Locus tag Dpoa569_RS17585 Protein ID WP_042868180.1
Coordinates 3917996..3918475 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A3N0G0N1
Locus tag Dpoa569_RS17580 Protein ID WP_019843650.1
Coordinates 3917733..3918005 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dpoa569_RS17555 3913458..3914174 - 717 WP_042868187.1 ABC transporter ATP-binding protein -
Dpoa569_RS17560 3914228..3915478 - 1251 WP_042868186.1 HlyD family efflux transporter periplasmic adaptor subunit -
Dpoa569_RS17565 3915908..3916453 + 546 WP_042868185.1 AraC family transcriptional regulator -
Dpoa569_RS17570 3916465..3916710 - 246 Protein_3418 HipA domain-containing protein -
Dpoa569_RS17575 3916783..3917196 - 414 Protein_3419 site-specific integrase -
Dpoa569_RS17580 3917733..3918005 + 273 WP_019843650.1 DUF1778 domain-containing protein Antitoxin
Dpoa569_RS17585 3917996..3918475 + 480 WP_042868180.1 GNAT family N-acetyltransferase Toxin
Dpoa569_RS17590 3918663..3919865 - 1203 WP_146410909.1 IS256 family transposase -
Dpoa569_RS17595 3920130..3921062 - 933 WP_042868178.1 HrgA protein -
Dpoa569_RS17600 3921294..3921515 - 222 Protein_3424 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3913458..3936524 23066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-85)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17587.37 Da        Isoelectric Point: 9.5371

>T135015 WP_042868180.1 NZ_CP042220:3917996-3918475 [Dickeya poaceiphila]
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTHRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFIPSEIQEHTLLLSLW

Download         Length: 480 bp

>T135015 NZ_CP042220:3917996-3918475 [Dickeya poaceiphila]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCAGTTGTGGATTTTCATTGTTCAGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAGGCGTTAAAAAATCAGACACTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGTACACATC
GTGTGGTGGGGTTCTATGCCCTCGCGTCGGGTAGCATCCAGCGTCAGGTTGCACCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTACTTGGCCGATTAGCCGTTGATGAACGTTATCAACGTATGGGGATCGGTGCCGGGCTTCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCGTTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTATCCCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10388.86 Da        Isoelectric Point: 4.6702

>AT135015 WP_019843650.1 NZ_CP042220:3917733-3918005 [Dickeya poaceiphila]
MRTETKEMPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRVN
ALLNRKSPWE

Download         Length: 273 bp

>AT135015 NZ_CP042220:3917733-3918005 [Dickeya poaceiphila]
ATGCGAACAGAGACAAAAGAAATGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCTGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAAGATGTGTTGTTGGATCAACGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGTTGGAATCACCAGTCACAGATAATCCGCGTGTGAAT
GCATTACTGAACAGGAAATCTCCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B8IDH8

Antitoxin

Source ID Structure
AlphaFold DB A0A3N0G0N1

References