Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3656163..3656841 Replicon chromosome
Accession NZ_CP042220
Organism Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)


Gene name cptA Uniprot ID A0A5B8II55
Locus tag Dpoa569_RS16385 Protein ID WP_042868574.1
Coordinates 3656163..3656594 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5B8IAQ1
Locus tag Dpoa569_RS16390 Protein ID WP_042868572.1
Coordinates 3656575..3656841 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dpoa569_RS16365 3652153..3652869 - 717 WP_146411557.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
Dpoa569_RS16370 3652962..3653861 - 900 WP_146411560.1 site-specific tyrosine recombinase XerD -
Dpoa569_RS16375 3654125..3655450 + 1326 WP_042868579.1 MHS family MFS transporter -
Dpoa569_RS16380 3655579..3656097 + 519 WP_042868577.1 flavodoxin FldB -
Dpoa569_RS16385 3656163..3656594 - 432 WP_042868574.1 protein YgfX Toxin
Dpoa569_RS16390 3656575..3656841 - 267 WP_042868572.1 FAD assembly factor SdhE Antitoxin
Dpoa569_RS16395 3657142..3658122 + 981 WP_042868571.1 tRNA-modifying protein YgfZ -
Dpoa569_RS16400 3658208..3658858 - 651 WP_042868568.1 hemolysin III family protein -
Dpoa569_RS16405 3659213..3659821 + 609 WP_042868565.1 HD domain-containing protein -
Dpoa569_RS16410 3659882..3660535 - 654 WP_042868563.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-78)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16984.65 Da        Isoelectric Point: 10.2088

>T135013 WP_042868574.1 NZ_CP042220:c3656594-3656163 [Dickeya poaceiphila]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFDFVRSQRTIKSRQGEISLHDENQLHWQNR
DWQIVRRPWVMRNGVLLSLRAVDGKGHQRLWLASDSMDCEEWRLLRQLLQQHPLQGTQSSRHH

Download         Length: 432 bp

>T135013 NZ_CP042220:c3656594-3656163 [Dickeya poaceiphila]
GTGGCCCAGTGGCAATGTGATTTGCGCGTATCCTGGCGTATGCAGCTGTTTTCGCTGCTGACGCACGGATTTCTGGTGCT
GATGATTCTGCTGGCTCCATGGCCGGACGGCTATGCGCCGTTGTGGCTAGGACTGGTGACGCTGGTGGTGTTCGATTTCG
TGCGTAGCCAGCGCACCATCAAGTCACGTCAGGGGGAAATCTCCCTGCACGACGAGAACCAACTACATTGGCAGAACCGT
GACTGGCAGATAGTCCGACGGCCTTGGGTAATGCGCAACGGCGTGTTGCTGTCGTTGCGTGCGGTGGATGGCAAGGGGCA
TCAGCGCCTGTGGCTGGCATCAGACAGTATGGATTGCGAAGAGTGGCGGCTGTTACGCCAGTTATTGCAGCAACACCCGT
TACAGGGAACGCAATCTTCCCGGCATCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.07 Da        Isoelectric Point: 5.5981

>AT135013 WP_042868572.1 NZ_CP042220:c3656841-3656575 [Dickeya poaceiphila]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPVDPGLKRMISLIQMRN
KDRGPVAM

Download         Length: 267 bp

>AT135013 NZ_CP042220:c3656841-3656575 [Dickeya poaceiphila]
ATGGATATCAATAATAAAGCACGCATTCACTGGGCGTGCAGGCGCGGAATGCGCGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACACTGAGCGACGACGACAAGCAACAGTTTATTCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAATTGGTTGATGAACCATGGCGAGCCGGTCGATCCGGGTTTGAAACGCATGATTTCCCTTATTCAGATGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B8II55

Antitoxin

Source ID Structure
AlphaFold DB A0A5B8IAQ1

References