Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3531101..3531744 Replicon chromosome
Accession NZ_CP042220
Organism Dickeya poaceiphila strain NCPPB 569

Toxin (Protein)


Gene name vagD Uniprot ID A0A5B8IAR4
Locus tag Dpoa569_RS15815 Protein ID WP_042870892.1
Coordinates 3531101..3531517 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5B8IA56
Locus tag Dpoa569_RS15820 Protein ID WP_042870894.1
Coordinates 3531514..3531744 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dpoa569_RS15790 3526405..3526851 + 447 WP_000708540.1 hypothetical protein -
Dpoa569_RS15795 3526851..3528671 + 1821 WP_042868744.1 DUF3732 domain-containing protein -
Dpoa569_RS19460 3530462..3530779 - 318 Protein_3074 transposase -
Dpoa569_RS15810 3530925..3531077 - 153 WP_155683842.1 hypothetical protein -
Dpoa569_RS15815 3531101..3531517 - 417 WP_042870892.1 type II toxin-antitoxin system VapC family toxin Toxin
Dpoa569_RS15820 3531514..3531744 - 231 WP_042870894.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Dpoa569_RS15825 3532095..3534738 + 2644 Protein_3078 ankyrin repeat domain-containing protein -
Dpoa569_RS15830 3534838..3535461 - 624 WP_042870895.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3525209..3563566 38357


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15143.56 Da        Isoelectric Point: 7.1351

>T135012 WP_042870892.1 NZ_CP042220:c3531517-3531101 [Dickeya poaceiphila]
VNNIYMLDTNICSFIMREQPEVVIKKLEQSVLRNQRIVVSAITYAEMRFGATGPKASPRHIQLVDEFCARLDAILPWDRA
AVDATTDIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTMEDWVK

Download         Length: 417 bp

>T135012 NZ_CP042220:c3531517-3531101 [Dickeya poaceiphila]
GTGAATAACATTTACATGCTGGACACCAACATCTGCTCGTTCATCATGCGCGAGCAACCGGAAGTCGTGATAAAAAAACT
TGAACAGTCGGTGCTGCGTAACCAGCGGATTGTGGTCTCGGCTATCACCTATGCCGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCGCCACGCCACATTCAGCTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGTGCC
GCTGTGGACGCCACCACGGACATTAAAGTGGCGCTGCGGCTGGCCGGGACCCCCATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCCATTGCCGCCGGTGCCGTGCTGGTGACGAATAATGTGCGGGAGTTTGCGCGGGTGCCCGGCCTGACAATGG
AAGACTGGGTAAAATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8768.84 Da        Isoelectric Point: 4.4870

>AT135012 WP_042870894.1 NZ_CP042220:c3531744-3531514 [Dickeya poaceiphila]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVRDGDRIILRPVRPTWGSFAQLEKADSDFMAEREDVVSDEGRFDL

Download         Length: 231 bp

>AT135012 NZ_CP042220:c3531744-3531514 [Dickeya poaceiphila]
ATGCGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGTTTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAACTGGAGATCGTCCGCGACGGGGACAGAATCATCCTGCGTCCCGTCCGCCCGACTTGGGGTTCGTTCGCTCAGTTGG
AGAAGGCAGATTCGGATTTTATGGCGGAGCGCGAGGACGTGGTCAGCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5B8IAR4

Antitoxin

Source ID Structure
AlphaFold DB A0A5B8IA56

References